A new and easily regenerable NAD(P)H model 9,10-dihydrophenanthridine (DHPD) has been designed for biomimetic asymmetric hydrogenation of imines and aromatic compounds. This reaction features the use of hydrogen gas as terminal reductant for the regeneration of the DHPD under the mild condition. Therefore, the substrate scope is not limited in benzoxazinones; the biomimetic asymmetric hydrogena...

ABSTRACT Benzoxazine and its derivatives are used in organic synthesis for building natural and designed synthetic compounds and they have been frequently utilized as suitable skeletons for the design of biologically active compound. This review covers updated information on the most active benzoxazine derivatives that have been reported to show considerable pharmacological actions such as anti...

Dual copper catalysis, involving two different reactions, click (alkyne-azide) and carbon-oxygen bond formation (aryl iodide-secondary alcohol) in a single step, is reported. Synthesis of novel benzodioxines (benzodioxanes), benzoxazines, benzoxathiines and benzodioxepines, which feature benzo-condensed six or seven membered rings containing two hetero-atoms attached to a 1,2,3-triazole, is des...

In this work the electrooxidation half-wave potentials of some Benzoxazines were predicted from their structural molecular descriptors by using quantitative structure-property relationship (QSAR) approaches. The dataset consist the half-wave potential of 40 benzoxazine derivatives which were obtained by DC-polarography. Descriptors which were selected by stepwise multiple selection procedure ar...

Due to the importance of SCN-containing heteroarenes, developing novel and green synthetic protocols for synthesis compounds has drawn much attention over last decades. We reported here an electrochemical oxidative cyclization ortho-vinyl aniline access various benzoxazines. Mild conditions, extra catalyst-free oxidant-free system, good tolerance air highlight application potential this method.

Abstract Kinetic resolution provided a highly enantioselective method to access range of 3-aryl-3,4-dihydro-2H-1,4-benzoxazines using n-butyllithium and the chiral ligand sparteine. The enantioenrichment remained high on removing tert-butoxycarbonyl (Boc) protecting group. intermediate organolithium undergoes ring opening an enamine. kinetic was extended give enantiomerically enriched substitut...