We report the synthesis of a soluble perylene imide benzimidazole (PIBI) and its structural, thermotropic, optical and electrochemical characterization with emphasis on discotic liquid crystalline properties.

Ni2+ supported on hydroxyapatite-core@shell γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+) was found to be a useful catalyst for the synthesis of benzimidazole derivatives from o-phenylenediamine and aldehydes under solvent and solvent-free conditions at 80 °C. This reaction affords the corresponding benzimidazole derivatives compared with the classical reactions this method consistently gives a high...

BACKGROUND Benzimidazoles and triazoles are useful structures for research and development of new pharmaceutical molecules and have received much attention in the last decade because of their highly potent medicinal activities. FINDINGS A simple and efficient synthesis of triazole was carried out by treatment of 2-(4-azidophenyl)-1H-benzo[d]imidazole (6) with different types of terminal alkyn...

The design and synthesis of a series of methyl 5(6)-substituted benzimidazole-2-carbamates as possible anthelmintics have been described. A rational analysis of the structural parameters which segregate the activity of resulting benzimidazole-2-carbamates against enteric and tissue dwelling helminths is presented. The influence of single and multiple spacers, which link the pharmacophores at 5(...

Many drug molecules comprises of benzo fused heterocycles with two nitrogen atoms, that is, benzimidazole and its derivatives. biological active contain 2-aminobenzimidazole cores are among the foremost common structural components in medicinal chemistry. derivative have wide range pharmaceutical activities. In this review, authors summarize synthesis, various chemical reactions, activities der...

An efficient soluble polymer-supported method has been developed for the parallel synthesis of substituted benzimidazole linked benzoxazoles using focused microwave irradiation. The key step involves the amidation of 4-hydroxy-3-nitrobenzoic acid with polymer-immobilized o-phenylenediamine. Application of mild acidic conditions promoted the ring closure to furnish the benzimidazole ring. After ...

A new synthesis of 2-oxa-7-azaspiro[3.5]nonane is described. Spirocyclic oxetanes, including 2-oxa-6-azaspiro[3.3]heptane were converted into o-cycloalkylaminoacetanilides for oxidative cyclizations using Oxone® in formic acid. The expanded spirocyclic oxetane successfully gave the [1,2-a] ring-fused benzimidazole. X-ray crystal structure of the resultant new tetracyclic system, 1',2'-dihydro-4...

A one-pot multicomponent reaction of aryl aldehydes, 2-amino benzimidazole and ethyl 2-mercaptoacetate is described as an efficient and environmentally method for the synthesis of  some  novel  ethyl  2-((1H-benzo[d]imidazol-2-ylamino)(Aryl)methylthio)  acetates  in  the presence of nano-Copper Y Zeolite (NCZ) as a catalyst in ethanol at room temperature. After optimizing of r...

A straightforward method has been developed for the synthesis of the benzimidazole ring system through a carbon-nitrogen cross-coupling reaction. In the presence of 2.0 equiv. of K(2)CO(3) in water at 100 °C for 30 h, the intramolecular cyclization of N-(2-iodoaryl)benzamidine provides benzimidazole derivatives in moderate to high yields. Remarkably, the procedure occurs exclusively in wat...