The purpose of this research was to study the neutralization efficacy of a universal neutralizer proposed by the CTPA on a range of antimicrobial agents and its potential toxicity for microorganisms that are used for antimicrobial preservation testing. Several types of antimicrobial agents including a mixture of methylisothiazolinone and its 5-chloro derivative, dimethylol dimethyl hydantoin, Q...

background today, the use of cyclodextrins (cds) is a major concern in drug formulations to improve solubility and stability of compounds. it has been known that cds can reduce the antimicrobial effectiveness of preservatives by formation of inclusion complexes. objectives in this study the interaction between commonly used preservatives, benzalkonium chloride (bzcl) or methyl paraben (mp), wit...

Środki konserwujące używane w preparatach okulistycznych to związki chemiczne o działaniu bakteriobójczym. Zapewniają jałowość leku, zapobiegając przypadkowej kontaminacji mikroorganizmami i rozwojowi opakowaniu drobnoustrojów, które mogą spowodować infekcję tkanek oka, a dodatkowo zmienić właściwości fizykochemiczne substancji czynnej. W okulistyce najczęściej wykorzystywanym konserwantem jest...

Medical therapy is the first-line option in glaucoma management, with benzalkonium chloride (BAC) being the most frequently used preservative in antiglaucoma medications. Its use is however, known to be associated with deleterious effects on the ocular surface. This review is an attempt to critically evaluate whether BAC really is indispensable for better bioavailability of antiglaucoma drugs a...

Benzalkonium chloride, a surface-active preservative commonly used in eyedrop preparations, has been shown to hasten the drying of the precorneal tear film. In the rabbit, 0.01 per cent benzalkonium (the concentration usually employed as a preservative) shortened the time required for the appearance of dry spots on the corneal surface by a factor of about four. In man, an approximately twofold ...

Analysis of the effects of deoxycholate and benzalkonium chloride on granule relaxing activity, myofibril and glycerinated fiber responses to ATP, and the sensitivity of these actomyosin-containing systems to relaxing factors have established that it is possible to differentially inactivate intrinsic granule relaxing factor. It is therefore possible to use these agents to treat myofibrils and g...

Six automated instruments that measure sodium and potassium were tested for interference from two compounds used in catheters. Tridodecylmethylammonium heparin did not interfere with any of the methods. However, benzalkonium heparin falsely increased sodium measurement with the Kodak Ektachem, and falsely increased potassium measurements with three instruments (Beckman Astra, Baxter Paramax, an...

fungicidal efficiency of iranian made benzalkonium chloride named akhgar, afshang and hamoon were evaluated on pure culture species of aspergillus nijer, candida ablicans and mucour according to the standard method no. 2442 issued by the institute of standards and industrial research of iran, from october 1993 to march 1994. suspensions were prepared in a way that each cubic centimeter having 3...

the purpose of this research was to study the neutralization efficacy of a universal neutralizer proposed by the ctpa on a range of antimicrobial agents and its potential toxicity for microorganisms that are used for antimicrobial preservation testing. several types of antimicrobial agents including a mixture of methylisothiazolinone and its 5-chloro derivative, dimethylol dimethyl hydantoin, q...

zinc sulphate and boric acid ophthalmic preparations, containing benzalkonium chloride as preservative, have been investigated against gram-negative and positive bacteria. viability of bacteria was found after 7 days, although it was completely suppressed after 24 hours of inoculation. zinc sulphate generally increases the antimicrobial activity of benzalkonium chloride, whereas boric acid or i...