The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular processes. An overactivation of the pathway is frequently present in human malignancies and plays a key role in cancer progression. Hence, its inhibition has become a promising approach in cancer therapy. However, the development of resistances, such as the abrogation of negative feedback mechanisms or th...

The 3D structures of all 12 mispairs formed in the active site of a DNA polymerase help explain their differential effects on polymerase stalling and on translocation of the primer terminus to the enzyme's proofreading site.

A complex hyperbolic triangle group is the group of complex hyperbolic isometries generated by complex involutions fixing three complex lines in complex hyperbolic space. Such a group is called equilateral if there is an isometry of order three that cyclically permutes the three complex lines. We consider equilateral triangle groups for which the product of each pair of involutions and the prod...

Men may have evolved psychological mechanisms that motivate mate retention behaviors to prevent their partners from being sexually unfaithful or defecting from the relationship because these events are likely to have inflicted reproductive costs on males over human evolutionary history. In the current research, 235 women provided information about their own and their long-term partners’ mate va...

Pyloric duplication cyst is a rare congenital anomaly. Few cases have been described in the literature. We report two cases of 2 and 5 year-old girl. The diagnosis was suspected on ultra sonography and upper gastrointestinal series and confirmed by surgery and histopathologic examination. Resection was total in one case and partial in the other. Pyloroplasty was associated. Post operative was u...

tresses were unfaithful to them. As murderers go, they were an elderly group, of average age 474 years. Unlike ordinary, jealous lovers, their attacks were nearly always upon wives, rather than upon supposed rivals. The latter, being imaginary, could never be caught in the act and were only hazily identified. As with most deluded patients, these murderers seemed driven by emotional necessity to...

A commitment to an integrative, non-reductionist clinical and theoretical perspective in medicine that honors the importance of all relevant domains of knowledge, not just "the biological," is clearly evident in Engel's original writings on the biopsychosocial model. And though this model's influence on modern psychiatry (in clinical as well as educational settings) has been significant, a grow...