PURPOSE The Toll-like receptor (TLR) 9 ligand CpG has been used successfully for the immunotherapy of cancer. Chronic CpG application in tumor-free hosts leads, however, to the expansion of myeloid-derived suppressor cells (MDSC), which can cause T-cell suppression and may thus hamper the development of an effective immune response. Here, we investigated the effect of TLR9 activation on the fun...

The purpose of this prospective randomized study was to compare the postoperative recovery and early results of 2 groups of patients undergoing total knee arthroplasty: 107 patients received an established fixed-bearing posterior-stabilized prosthesis (Legacy Posterior Stabilized [LPS]), and 103 patients the meniscal-bearing prosthesis (Meniscal Bearing Knee [MBK]). Surgical procedures were the...

We investigated the anti-tumour effect of polysaccharides from Solanum nigrum Linne, and its relationship with the immune function of tumour-bearing organisms. MTT assay was used to observe the effect of different doses of polysaccharides from Solanum nigrum Linne on proliferation of lymphocytes in tumour-bearing mice. ELISA assay was also used to detect the levels of IL-2 in mice, and a laser ...

NK cells, the important effector of innate immunity, play critical roles in the antitumor immunity. Myeloid-derived suppressor cells (MDSC), a population of CD11b(+)Gr-1(+) myeloid cells expanded dramatically during tumor progression, can inhibit T cells and dendritic cells, contributing to tumor immune escape. However, regulation of NK cell innate function by MDSC in tumor-bearing host needs t...

abstract background: correction of the uremic state by a functioning allograft often restores fertility in women of reproductive age. the rate of fertility significantly differs between industrial countries, developing and middle east countries. on the other hand the results of pregnancy in kidney transplantation (ktp) patients are significantly better than hemodialysis patients, and pregnancy ...

One of the chief obstacles to constructing a reliable, low-cost, practical magnetic bearing is designing a suitable position sensor. A homopolar magnetic bearing that uses the same coils to stabilize the rotor and sense its position is introduced. A prototype bearing has been built and successfully used to stabilize a rotor. The electromagnetic analysis of the self-sensing function, the impleme...

BACKGROUND Lymphocytes from tumor-bearing animals have been shown to lack antitumor function. The objective of this study was to investigate the status of the signal transducers, Stat1 and Stat3, in T lymphocytes of animals bearing D1-DMBA-3 mammary tumors and to elucidate if any alterations in these signal transducers can be explained by the presence of tumor-derived factors and correlated wit...

background: appropriate endurance exercise can change bone mass density and strength of weight-bearing bones in both animals and humans, but its effects on the microstructure are not known. this study aimed to determine skeletal changes induced by the treadmill running endurance in ovariectomized adult mice. methods: twenty-seven adult female rats were divided into experimental and control grou...