The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted due to adverse cardiovascular events in chronic kidney disease patients, although the underlying mechanisms are yet to be resolved. The majority...

Running head: Pyoverdine impact on plant growth/defense balance 1 2 Corresponding author: 3 Dr. Angélique BESSON-BARD 4 Université De Bourgogne Franche-Comté, UMR1347 Agroécologie, ERL CNRS 6300, BP 5 86510, F-21000 Dijon, France 6 Tel: +33 (0)3 80 69 31 78 7 Email: [email protected] 8 9 Research area: Signaling and Response 10 Plant Physiology Preview. Published on March 8, 2...

Previous disfluency studies have argued that disfluencies are strategic signals to a listener in times of difficulty (Clark & Wasow, 1998). Other research suggests that disfluencies are a possible indication of cognitive overload (Bard et al., 2000). Bard et al. (2003) demonstrate that interaction with a Follower could induce more difficulties for a speaker. The current paper tests these hypoth...

AC’s employer, on her behalf, has received investigator-initiated research grants from Cardinal Health and Eloquest Healthcare (unrelated to current project). JAS discloses that or previous employer behalf: BD-Bard unrelated project.

Background Non-invasive fibrosis scores are not yet validated in the newly defined metabolic associated fatty liver disease (MAFLD). Aim To evaluate diagnostic performance of four non-invasive including aspartate aminotransferase to platelet ratio index (APRI), fibrosis-4 (FIB-4), body mass index, aminotransferase/alanine ratio, diabetes score (BARD), and nonalcoholic (NFS) patients with MAFLD....

Shakespeare's obsessive interest in syphilis, his clinically exact knowledge of its manifestations, the final poems of the sonnets, and contemporary gossip all suggest that he was infected with "the infinite malady." The psychological impact of venereal disease may explain the misogyny and revulsion from sex so prominent in the writings of Shakespeare's tragic period. This article examines the ...