Steroid monooxygenase (STMO) from Rhodococcus rhodochrous catalyzes the Baeyer-Villiger conversion of progesterone into progesterone acetate using FAD as prosthetic group and NADPH as reducing cofactor. The enzyme shares high sequence similarity with well characterized Baeyer-Villiger monooxygenases, including phenylacetone monooxygenase and cyclohexanone monooxygenase. The comparative biochemi...

The development of effective, environmentally friendly catalysts for the Baeyer–Villiger reaction is becoming increasingly important in applied catalysis. In this work, we synthesized a 3D composite consisting silica spheres coated with Mg/Al hydrotalcite much better textural properties than its 2D counterparts. fact, solid outperformed 2D-layered as catalyst cyclic ketones H2O2/benzonitrile ox...

Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands th...

Submit Manuscript | http://medcraveonline.com organic solvents like benzene, methanol, toluene are carcinogenic and can be toxic to human health and cause an environmental menace by polluting the atmosphere. The replacement of volatile organic solvents in organic reaction is an important aim of green chemistry [3,4]. Earliest known examples of organic synthesis in water include Wohler’s urea sy...