B-5354c is a new inhibitor of sphingosine kinase from a novel marine bacterium, SANK 71896. Kinetic study revealed that B-5354c inhibits sphingosine kinase with a Ki value of 12/microM. The inhibition is noncompetitive with respect to sphingosine. The compound also inhibits sphingosine-1-phosphate formation in human platelets. Experiments using synthetic derivatives of B-5354c indicate that all...

background: in this study, we determine the vector competence of musca domestica with reference to the transmis­sion of susceptible and resistance bacterial strains in hospitals and slaughter house in sanandaj city, west iran. methods: totally 908 houseflies were collected to isolate bacteria from their external body based on standard proce­dures.antibiotic susceptibility testing was performed ...

The aim of treatment of Helicobacter pylori is eradication of the bacterium from the foregut. Treatment is difficult because of the bacterium's habitat and acquired resistance to commonly used antibiotics. Dual therapy, the 2 week combination of omeprazole or ranitidine bismuth citrate and either amoxycillin or clarithromycin, eradicates H. pylori in 50-80% of patients. Classical triple therapy...

Molybdenum reduction to molybdenum blue by microbes is a potential bioremediation tool for molybdenum pollution. A previous work using cyanide as a respiratory inhibitor has shown that the site of molybdenum reduction in Enterobacter cloacae strain 48 is at the electron transport pathway. In the present work, several respiratory inhibitors together with cyanide were used to reinvestigate the si...

background and objectives: the objective of this study was to monitor the microorganisms isolated from grapes and its derivative traditional products produced in iran. material and methods: four kinds of grapes cultivated summer of 2010 in vineyard of takestan and also grape derived products from shahrod, hamedan and takestan were used for this study.  the samples were cultured in specific medi...

bioleaching is the extraction of metals from their ores through the use of microorganisms. inthis process, the use of native bacteria leads to achieve more yields of metals. so, in the presentstudy, native sulfur-oxidizing bacterium in potentiality of uranium extraction was isolated fromghachin mine in iran and identified by partial gene sequencing. for this purpose, the watersamples were colle...

Brucella is an intracellular parasitic bacterium that uses multiple strategies to evade the host’s defense mechanisms. However, how manipulates host-induced oxidative stress and relevant biological processes are still poorly understood. In this study, a comparative transcriptome assay of macrophages infected with abortus S2308 its rough mutant RB14 was performed investigate differentially expre...

purpose : identifying the predisposing factors of the infectious keratitis results in understanding the underlying mechanisms of its expansion and severity that is essential for initiation of optimal empirical antimicrobial therapy. this study identified main predisposing factors of bacterial keratitis in a sample of iranian population. methods : ninety patients with bacterial keratitis were pr...