Multidrug resistance and toxicity associated with antimicrobial agents among pathogenic bacteria leading to a surge in morbidity mortality humans need bold proclamation the area of research development new biological agents. The maximum propitious possibility we can see bacteriocins. Bacteriocins are ribosomally synthesized peptides produced by gram-positive gram-negative which evince wide narr...

This study presents the characterization of eight bacteriocins produced by lactic acid bacteria (LAB) previously isolated from a traditional cheese, Pico cheese. All isolates were active against Listeria monocytogenes and only three against Clostridium perfringens. Bioactivity was studied after treatment with different enzymes, organic solvents, surfactants, temperature, pH and NaCl. The antimi...

Azurin from Pseudomonas aeruginosa is known anticancer bacteriocin, which can specifically penetrate human cancer cells and induce apoptosis. We hypothesized that pathogenic and commensal bacteria with long term residence in human body can produce azurin-like bacteriocins as a weapon against the invasion of cancers. In our previous work, putative bacteriocins have been screened from complete ge...

Bacteria produce a wide arsenal of toxic compounds in order to kill competing species. Bacteriocins, protein-based toxins produced by nearly all bacteria, have generally been considered a ubiquitous anti-competitor strategy, used to kill competing bacterial strains. Some of these bacteriocins are encoded on plasmids, which also code for closely linked immunity compounds (thereby rendering toxin...

Bacteriocins are described as ribosomally synthesized small poly peptides that exert antimicrobial effects against closely or non-closely related bacteria. The major producer group for bacteriocins is lactic acid bacteria (LAB) that contain a great variety of microorganisms described as “generally recognized as safe (GRAS)” by the US Food and Drug Administration. Due to this accredited safety p...

Recent developments in the application of bacteriocin-producing bacteria to preserve food and maintain its safety are reviewed. The aim is to create a comprehensive compilation of advances in the applications of bacteriocins or the bacteria that produce them. Bacteria reviewed possess genetic mechanisms to produce, modify and export bacteriocins as well as genetic mechanisms to avoid self destr...

OBJECTIVE Bacterial vaginosis is associated with an unexplained loss of vaginal lactobacilli. Previously, we have identified certain vaginal lactobacilli-released phages that can inhibit in vitro other vaginal lactobacilli. However, there is no apparent route for phages to be transmitted among women. The purpose of this study was to identify whether certain Lactobacillus products commonly used ...

Lactobacillus plantarum F1 and L. brevis OG1 isolated from Nigerian fermented food products, produced bacteriocins that had broad spectrum of inhibition against both pathogenic, food spoilage organisms and various lactic acid bacteria. The test organisms exhibited activities of 6400 and 3200 AU/ml respectively against Escherichia coli NCTC10418 and Enterococcus faecalis EF1, but did not inhibit...

Bacteria host an arsenal of antagonism-mediating molecules to combat for ecologic space. Bacteriocins represent a pivotal group of secreted antibacterial peptides and proteins assisting in this fight, mainly eliminating relatives. Colicin M, a model for peptidoglycan-interfering bacteriocins in Gram-negative bacteria, appears to be part of a set of polymorphic toxins equipped with such a cataly...

Cancer remains one of the leading causes of deaths worldwide, despite advances in its treatment and detection. The conventional chemotherapeutic agents used for the treatment of cancer have non-specific toxicity toward normal body cells that cause various side effects. Secondly, cancer cells are known to develop chemotherapy resistance in due course of treatment. Thus, the demand for novel anti...