نتایج جستجو برای: bacterial barrier

تعداد نتایج: 291925  

2014
Ulf A. Wenzel Maria K. Magnusson Anna Rydström Caroline Jonstrand Julia Hengst Malin EV. Johansson Anna Velcich Lena Öhman Hans Strid Henrik Sjövall Gunnar C. Hansson Mary Jo Wick

BACKGROUND The colonic mucus layer plays a critical role in intestinal homeostasis by limiting contact between luminal bacteria and the mucosal immune system. A defective mucus barrier in animal models allows bacterial contact with the intestinal epithelium and results in spontaneous colitis. A defective mucus barrier is also a key feature of active ulcerative colitis (UC). Alterations in the i...

Journal: :Nutrients 2015
Xiao Wan Jingcheng Bi Xuejin Gao Feng Tian Xinying Wang Ning Li Jieshou Li

Lack of enteral nutrition (EN) during parenteral nutrition (PN) leads to higher incidence of infection because of gut barrier dysfunction. However, the effects of partial EN on intestina linnate immunity, intestinal alkaline phosphatase (IAP) and microbiota remain unclear. The mice were randomized into six groups to receive either standard chow or isocaloric and isonitrogenous nutritional suppo...

2016
Adriaan A. van Beek Bruno Sovran Floor Hugenholtz Ben Meijer Joanne A. Hoogerland Violeta Mihailova Corine van der Ploeg Clara Belzer Mark V. Boekschoten Jan H. J. Hoeijmakers Wilbert P. Vermeij Paul de Vos Jerry M. Wells Pieter J. M. Leenen Claudio Nicoletti Rudi W. Hendriks Huub F. J. Savelkoul

Although it is clear that probiotics improve intestinal barrier function, little is known about the effects of probiotics on the aging intestine. We investigated effects of 10-week bacterial supplementation of Lactobacillus plantarum WCFS1, Lactobacillus casei BL23, or Bifidobacterium breve DSM20213 on gut barrier and immunity in 16-week-old accelerated aging Ercc1-/Δ7 mice, which have a median...

Journal: :Clinical and investigative medicine. Medecine clinique et experimentale 2010
Huichi Hou Xiaochun Ping Yanfei Zhu Zengshun Zhao Yousheng Li Jieshou Li

BACKGROUND Damage to the intestinal barrier often occurs following severe trauma. It has been reported that enteral nutrition with dietary fiber (DF) could mitigate impairment of the intestinal barrier and might therefore be effective in clinical application; however, the conclusions from existing trials are controversial and the nature of the protective mechanism is far from clear. This study ...

Journal: :Cell 2016
Javier Estrada Felix Wong Angela DePace Jeremy Gunawardena

The quantitative concepts used to reason about gene regulation largely derive from bacterial studies. We show that this bacterial paradigm cannot explain the sharp expression of a canonical developmental gene in response to a regulating transcription factor (TF). In the absence of energy expenditure, with regulatory DNA at thermodynamic equilibrium, information integration across multiple TF bi...

Journal: :Pharmacological reviews 1997
H E de Vries J Kuiper A G de Boer T J Van Berkel D D Breimer

I. The blood-brain barrier . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 A. Morphology and function. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 B. Mechanisms of transport of compounds across the blood-brain barrier . . . . ....

Journal: :Journal of applied physiology 2011
Junjie Xing Nurgul Moldobaeva Anna A Birukova

Lung inflammation and alterations in endothelial cell (EC) permeability are key events to development of acute lung injury (ALI). Protective effects of atrial natriuretic peptide (ANP) have been shown against inflammatory signaling and endothelial barrier dysfunction induced by gram-negative bacterial wall liposaccharide. We hypothesized that ANP may possess more general protective effects and ...

Journal: :The Journal of infectious diseases 2014
Sylvie Y Doerflinger Andrea L Throop Melissa M Herbst-Kralovetz

BACKGROUND Bacterial vaginosis increases the susceptibility to sexually transmitted infections and negatively affects women's reproductive health. METHODS To investigate host-vaginal microbiota interactions and the impact on immune barrier function, we colonized 3-dimensional (3-D) human vaginal epithelial cells with 2 predominant species of vaginal microbiota (Lactobacillus iners and Lactoba...

2013
Javier Rivera Guzman Victoria Susan Conlin Christian Jobin

The intestinal epithelium represents a critical barrier protecting the host against diverse luminal noxious agents, as well as preventing the uncontrolled uptake of bacteria that could activate an immune response in a susceptible host. The epithelial monolayer that constitutes this barrier is regulated by a meshwork of proteins that orchestrate complex biological function such as permeability, ...

2017
Ming Li Bing Wang Xiaotong Sun Yan Tang Xiaoqing Wei Biying Ge Yawei Tang Ying Deng Chunyang He Jieli Yuan Xia Li

Bacterial consortium transplantation (BCT) is a promising alternative to fecal microbiota transplantation in treating inflammatory bowel disease (IBD). Here, we showed that a defined bacterial consortium derived from healthy mice was able to enhance the intestinal barrier function of mice with dextran sulfate sodium (DSS)-induced colitis. Interestingly, we found that the bacterial consortium si...

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