STX209 is an exploratory drug comprising the single, active R-enantiomer of baclofen which is in later stage clinical trials for the treatment of fragile x syndrome (FXS) and autism spectrum disorders (ASD). New clinical data in this article on the metabolism and pharmacokinetics of the R- and S-enantiomers of baclofen presents scientific evidence for stereoselective metabolism of only S-baclof...

TO THE EDITOR I read with interest the case report on baclofen abuse by Ghosh and Bhuyan in May issue of Clinincal Psychopharmacology and Neuroscience 2017. The patient reportedly was prescribed quetiapine 100 mg, escitalopram 20 mg, mirtazapine 15 mg, lorazepam 2 mg and baclofen 20 mg after initial detoxification, for depression and insomnia along with relapse prevention. As mentioned, escital...

AIMS The purpose of this study was to examine the long-term effects of baclofen in a large cohort of alcohol-dependent patients compliant to baclofen treatment. METHODS A hundred patients with alcohol dependence, resistant to usual treatments, were treated with escalating doses of baclofen (no superior limit). Alcohol consumption (in grams) and craving for alcohol were assessed before treatme...

A middle-aged woman began experiencing spells of profound anterograde amnesia several months after beginning intrathecal baclofen treatment for generalized dystonia. Her spells met criteria for transient global amnesia, but were unusual because of their frequent recurrence and because their frequency was somewhat dose-dependent on baclofen. Fludrocortisone decreased the frequency of these episo...

The influence of the blockade of group I metabotropic glutamate receptors (I mGluRs) by AIDA on some behavioral effects of rats pretreated with baclofen, an agonist of GABA-B receptor, was investigated using behavioral tests: the open field, the passive avoidance response and the elevated "plus" maze. Baclofen, applied intraperitoneally (ip) at a dose of 0.25 mg/kg, increased the number of cros...

Baclofen is used to manage alcohol dependence. This study describes a simple method using liquid chromatography coupled to high-resolution mass spectrometry (LC-HR-MS) developed in plasma samples. This method was optimized to allow quantification of baclofen and determination of metabolic ratio of its metabolites, an oxidative deaminated metabolite of baclofen (M1) and its glucuronide form (M2)...

One important function of GABA B receptors is the control neuronal activity to prevent overexcitation and thereby excitotoxic death, which a hallmark cerebral ischemia. Consequently, sustained activation with selective agonist baclofen provides neuroprotection in vitro vivo models However, conditions severely downregulate receptors, would compromise neuroprotective effectiveness baclofen. On ot...

BACKGROUND The results of preclinical studies suggest that baclofen may be useful in the treatment of stroke patients with persistent hiccups. This study was aimed to assess the possible efficacy of baclofen for the treatment of persistent hiccups after stroke. METHODS In total, 30 stroke patients with persistent hiccups were randomly assigned to receive baclofen (n = 15) or a placebo (n = 15...

Inhibition mediated by GABA-B receptors can play a role in epilepsy. We therefore studied its involvement in cortical epileptic afterdischarges in adult rats by means of a GABA-B receptor agonist baclofen. Three different experiments were performed with cortical epileptic afterdischarges and an additional experiment studied possible effect of baclofen on cortical interhemispheric (transcallosal...