Introduction: The major histocompatibility complex (MHC) is a group of cell surface proteins that are essential for recognizing foreign molecules in human and other mammals. The physiologic function of MHC molecules is the presentation of peptides to T cells. In this study, we evaluated the purification of a class II MHC molecule (HLA-DR) from a human Burkitt′s lymphoma cell line; Daudi...

the drb3 gene is a highly polymorphic major histocompatibility complex (mhc) class ii gene and plays an important role in variability of immune responsiveness and disease resistance. in the present study, the mhc class ii drb3 gene in water buffalo (bubalus bubalis) populations from northwest regions of iran was investigated through pcr-sscp. genomic dna was extracted from whole blood samples c...

The Major Histocompatibility Complex (MHC) genes play a key role in number of biological processes, most notably immunological responses. MHCI and MHCII incorporate complex set highly polymorphic polygenic series genes, which, due to the technical limitations previously available technologies, have only been partially characterized non-model but economically important species such as horse. adv...

Background The major histocompatibility complex (MHC) gene family, a vital immune family in vertebrates, helps animals defend against pathogens. polymorphism of MHC genes is important for species and considered to be caused by the numerous alleles antigen-presenting genes. However, mechanism this process unclear due lack data on structure. evolutionary trajectories tetrapod are also because ins...

Multiple sclerosis (MS) is an inflammatory disorder, in which neurons become demyelinated. To date, its etiology has remained unknown. Nevertheless, certain features are inspected to provoke MS. For instance, improper function of immune cells is widely believed to be the basis of such disorder. In this concept, MS is stated as an autoimmune disease, which was asserted by major of studies, as CD...

Background: Major histocompatibility complex (MHC) is one of the best characterized genetic regions controlling immune responses against vaccines. Identifying the association between MHC haplotypes and improved immune responses would be useful in genetic breeding strategies in animals. OBJECTIVES: MHC class II B genetic diversity and its association with humoral immune responses against Newcast...

CD8(+) T cells respond to signals mediated through a specific interaction between the T-cell receptor (TCR) and a composite antigen in the form of an epitopic peptide bound between the polymorphic α1 and α2 helices of an MHC class I (MHCI) molecule. The CD8 glycoprotein 'co-receives' antigen by binding to an invariant region of the MHCI molecule and can enhance ligand recognition by up to 1 mil...

The chicken major histocompatibility complex (MHC), or B complex, consists of several clusters of highly polymorphic genes, some of which are associated with disease resistance. The class I and class II antigens resemble their mammalian counterparts in the encoded protein structure. The class IV region encodes the B blood group antigens, which are readily identified by serological blood-typing....