نتایج جستجو برای: bach2
تعداد نتایج: 191 فیلتر نتایج به سال:
CONTEXT Autoimmune Addison's disease (AAD) is a rare but highly heritable condition. The BACH2 protein plays a crucial role in T lymphocyte maturation, and allelic variation in its gene has been associated with a number of autoimmune conditions. OBJECTIVE We aimed to determine whether alleles of the rs3757247 single nucleotide polymorphism (SNP) in the BACH2 gene are associated with AAD. DE...
Approximately 30% of the patients who fulfil the criteria of Waldenström's macroglobulinemia (WM) are diagnosed while asymptomatic (indolent), and will not require immediate therapy. Conversely, patients with a disease-related event will be considered for therapy. The physiopathology of these 2 groups remains unclear, and the mechanisms of progression from indolent to symptomatic WM have yet to...
Genetic studies have to date identified 43 genome wide significant coeliac disease susceptibility (CD) loci comprising over 70 candidate genes. However, how altered regulation of such disease associated genes contributes to CD pathogenesis remains to be elucidated. Recently there has been considerable emphasis on characterising cell type specific and stimulus dependent genetic variants. Therefo...
European Journal of ImmunologyVolume 52, Issue 11 Cover PictureFree Access Front cover story: Eur. J. Immunol. 11'22 First published: 03 November 2022 https://doi.org/10.1002/eji.202270110AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box below share version arti...
Senescence is a cellular process that can be initiated by certain stressors such as UVA irradiation. The mechanism which skin cells protect themselves from the UVA-induced senescence has not been fully investigated. Here, we demonstrate Bach2 modulates extent of photoaging through regulation autophagy in fibroblasts. In fact chronic exposure fibroblasts to resulted significant decrease expressi...
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