We isolated 45 Helicobacter pylori strains from 217 child patients. Resistance to clarithromycin, metronidazole, amoxicillin, and tetracycline was detected in 27%, 13%, 4%, and 0% of strains, respectively. The A2143G mutation was the most prevalent (67%) among clarithromycin-resistant strains. In addition, strain genotyping revealed a significant association between gastritis severity and the s...

Hiroshi Fujii1), Tomohisa Baba2), Masakazu Yamagishi3), Mitsuhiro Kawano1) and Naofumi Mukaida2, *) 1)Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan 2)Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan 3)Division of Cardiology, Department of Internal Medicine, Kanazawa ...

Infection with Helicobacter pylori is a major cause of chronic gastritis and peptic ulcer disease in children and its consequences in adulthood can lead to serious complications, including in particular the development of gastric cancer. Our aim was to analyze the relationship between the occurrence of selected genes such as cagA, vacA, iceA, and babA2 determining pathogenicity of H. pylori str...

The bacterium Helicobacter pylori exhibits great genetic diversity, and the pathogenic roles of its virulence factors have been widely studied. However, the evolutionary dynamics of H. pylori strains during stomach colonization are not well-characterized. Here, we analyzed the microevolutionary dynamics of the toxigenic strain vacAs1m1, the non-toxigenic strain vacAs2m2, and a combination of bo...

Heterogeneity among Helicobacter pylori strains in gastric epithelial adherence is postulated to contribute to pathogen fitness in the physiologically diverse human population. H. pylori adherence to ABO and Lewis b (Leb) blood group antigens in the human stomach is mediated by the blood group antigen-binding adhesin BabA. Approximately 70% of Swedish and U.S. H. pylori clinical isolates exhibi...

Background Although the causal relationship between Helicobacter pylori infection and the development of gastric cancer is firmly established, the exact nature of the pathogenicity factors of H. pylori that predispose to gastric oncogenesis remains incompletely characterized. We investigated the association between H. pylori virulence genotypes and disease in a well-characterized cohort consist...

results the frequency of the baba2, icea1 and icea2 genes in the total isolates were 34 (54%), 14 (22.2%) and 34 (54%), respectively. the association of these virulence factors based on sex and age groups were not statistically significant (p > 0.05). there was a borderline significant association between icea1 and the clinical outcomes (p = 0.094). patients and methods in this study, 63 positi...

helicobacter pylori (h. pylori) is classified as a class i carcinogen. the low infection rate seen in developed countries (8.9%) compared with a high infection rate (52%-98%) in developing countries indicates a strong association between infection prevalence and socioeconomic status. adhesion of h. pylori to gastric epithelial cells is an important aggressive factor. one of the genes that encod...