Several studies on the role of HCA species in regulating glucose homeostasis have indicated their therapeutic value human obesity and diabetes. There is a clear difference percentage hyocholic acid (HCA) its derivatives (also known as species) total bile (BA) pool plasma between humans, rats pigs. However, gut microbiota BA profiles pigs remains unclear. We generated five germ-free pig models s...

Hierdie navorsing is ’n omvattende studie in die hedendaagse verplecgonderwys met die klem op die onafhanklike benadering tot leer. Unisa word uitgeken as een van die eerste universiteite in die wêreld om teletuisie in tersiêre onderrig in te stel. Dit is ook die heel eerste universiteit om afstandsonderrig in te stel as nabasiese voortgesette onderrig vir geregLstreerde verpleegkundiges op die...

Phase II conjugating enzymes play key roles in the metabolism of xenobiotics. In the present study, RNA sequencing was used to elucidate hepatic ontogeny and tissue distribution of mRNA expression of all major known Phase II enzymes, including enzymes involved in glucuronidation, sulfation, glutathione conjugation, acetylation, methylation, and amino acid conjugation, as well as enzymes for the...

Freeways form an important part of the road network. Drivers’ behavior can be split in longitudinal (acceleration and deceleration) and lateral behavior (lane changing). The combination of these two behaviors on freeways play a key role in traffic operations. This paper tries to describe the driving behavior, emphasizing the relation between the lateral and longitudinal behavior. To this end, a...

Achtergrond en doel Kinderen met epilepsie scoren bij taalonderzoek meestal significant lager dan gezonde leeftijdgenoten. Tot beter begrip hiervan vergeleken wij kinderen farmacoresistente leeftijdgenoten in een benoemtaak als index van het lexicon. Onderzoeksvragen waren: verschillen de groepen aantallen goede benoemingen en/of hoeveelheid baat geboden hulp; hebben verwervingsleeftijd gebruik...

Activin A, a multifunctional cytokine, plays an important role in hepatocyte growth suppression and is involved in liver size control. The present study was aimed to determine the cell location of activin A in the normal rat liver microenvironment and the contribution of activin A signaling to the hepatocyte phenotype to obtain insight into molecular mechanisms. Immunohistochemical and in situ ...

This book is a celebration of the work of Peter· . . honor people by criticizing them Sing.' .f Smger. Smce philosophers come in for analysis and appr~isal .el tShi wn mlgs on a Wide array of topics . . III S vo ume Smger' t h· VieWS, his normative theory and h· b . . s me aet Ical , IS su stanttve posif h as the moral status of animals th . t f h IOns on suc matters are all subjected to scruti...

In human liver, unconjugated bile acids can be formed by the action of bile acid-CoA thioesterases (BACTEs), whereas bile acid conjugation with taurine or glycine (amidation) is catalyzed by bile acid-CoA:amino acid N-acyltransferases (BACATs). Both pathways exist in peroxisomes and cytosol. Bile acid amidation facilitates biliary excretion, whereas the accumulation of unconjugated bile acids m...

The Self is essentially a social structure and arises out of social experiences. There are different views about the concept of Self and the process of its differentiation. Autism is a complex neurobiological disorder that makes it hard for the people with autism to communicate with others and relate to the outside world. Since autistic people have problems in relating to the outer world, they ...

Despite its relevance to most UN Sustainable Development Goals (SDGs), nitrogen pollution still lacks broad visibility and coordinated global governance. A new goal “halve waste” by 2030 would save US$100 billion annually, contributing post-coronavirus disease 2019 (COVID-19) economic recovery multiple SDGs. The scientific community is working with the coordinate accelerate necessary action. If...