Administration of[3H]aflatoxin B2 (2,3-dihydroaflatoxin B1)(AFB2) to male rats resulted in levels of hepatic DNA- and ribosomal(r)RNA-aflatoxin adducts that were about 1% of those for rats given [3H]aflatoxin B1(AFB1). The levels of hepatic protein-aflatoxin adducts were 35 to 70% as great for AFB2-treated as compared to AFB1-treated rats...

This article describes clinical, etiologic and pathologic diagnosis of an outbreak of equine leukoencephalomalacia. Two samples of the corn consumed by the affected horses contained fumonisin B 1 at levels of 46 and 53 μg/g and Fusarium moniliforme, a good in vitro mycotoxin producer.

Aflatoxin B1-contaminated feeds and foods induce various health problems in domesticated animals humans, including tumor development hepatotoxicity. B1 also has embryotoxic effects different livestock species humans. However, it is difficult to distinguish between the indirect, maternally-mediated toxic direct embryotoxicity of aflatoxin mammals. In present study, we investigated B1-induced a z...

Table S1. Mean separation force (N) of explants incubated with FB1 (0–10 μg/mL) for 48 h (n = 9).

We investigated the effects of vitamin B1 deficiency on the meiosis maturation of oocytes. Female Crl:CD1 (ICR) mice were fed a 20% casein diet (control group) or a vitamin B1-free diet (test group). The vitamin B1 concentration in ovary was approximately 30% lower in the test group than in the control group. Oocyte meiosis was not affected by vitamin B1 deficiency when the deficiency was not a...

Mitosis is triggered by the activation of Cdk1-cyclin B1 and its translocation from the cytoplasm to the nucleus. Positive feedback loops regulate the activation of Cdk1-cyclin B1 and help make the process irreversible and all-or-none in character. Here we examine whether an analogous process, spatial positive feedback, regulates Cdk1-cyclin B1 redistribution. We used chemical biology approache...

BACKGROUND Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth. We tested the hypothesis that the expression of Plex-B1, either alone or in association with Met, can be of predictive value for tumour progressi...

B1 cells produce most natural Abs in unimmunized mice and play a key role in the response to thymus-independent Ags and microbial infection. Enlargement of B1 cell number in mice is often associated with autoimmunity. However, the factors that control peripheral B1 cell survival remain poorly characterized. Mice lacking the inhibitory receptor FcγRIIb exhibit a massive expansion in peritoneal B...

Purpose: This study aimed to understand the prognostic value of integrin b1 expression in head andneck squamous cell carcinoma (HNSCC) and themechanismunderlying its associationwithmetastatic HNSCC. Experimental Design: Archival HNSCC tissues including 99 nonmetastatic primary tumors and 101 metastatic primary tumors were examined for the association of integrin b1 expression with metastasis an...