B-cell superantigens (Sags) bind to conserved sites of the VH or VL regions of immunoglobulin molecules outside their complementarity-determining regions causing the apoptosis of normal cognate B cells. No attempts to investigate whether B-cell Sags are able to induce the apoptosis of cognate malignant B cells were reported. In the present study we show that protein L (PpL), secreted by Finegol...

Basal cell carcinoma (BCC) is the most common cutaneous malignancy and characterized by sustained Hedgehog (Hh) signaling. Despite major insights into molecular basis of BCC, relatively little known about how BCC tumor cells affect other types in microenvironment. It has been frequently observed that a subset tumors are clinically pigmented. Using immunostaining for melanocyte-specific antigens...

Breast cancer is the most common global malignancy and leading cause of deaths for women. Aromatase inhibitors are clinically recommended therapy disorders. However, resistance to aromatase therapies still occurs underlined molecular mechanisms poorly understood. The tumour specimens consisted inhibitor-sensitive inhibitor-resistant breast patients, who were compared differentially expressed ge...

<b><i>Introduction:</i></b> The homeodomain transcription factor sine oculis homeobox homolog 1 (Six1) plays a crucial role in embryogenesis and is not expressed normal adult tissue but many pathological processes, including airway remodelling asthma. current study aimed to reveal the effects of Six1 regulating its possible mechanism. <b><i>Methods:</i>...

Background: Gastric cancer is among the most common malignancies in certain parts of the world, such as northwest Iran. miRNAs are small and single-stranded noncoding RNAs with about 19-23 nucleotides. Several studies have shown that miRNAs play important roles in gastric tumorigenesis. The aim of this study was to determine the effect of miRNA-1266-5p repression on the cell survival and altera...

Background SLFN11 has recently been reported to execute cancer cells harboring replicative stress induced by DNA damaging agents. However, the roles of under physiological conditions remain poorly understood. Germinal center B-cells (GCBs) undergo somatic hypermutations and class-switch recombination, which can cause genotoxic stress. Hence, we tested whether expression needs be suppressed in G...

<b><i>Introduction:</i></b> Epicutaneous (e.c.) allergen exposure is an important route of sensitization toward allergic diseases in the atopic march. Allergen sources such as house dust mites contain proteases that involve pathogenesis allergy. Prostanoids produced via pathways downstream cyclooxygenases (COXs) regulate immune responses. Here, we demonstrate effects COX...