نتایج جستجو برای: azoles
تعداد نتایج: 1992 فیلتر نتایج به سال:
Widespread and repeated use of azoles, particularly fluconazole, has led to the rapid development of azole resistance in Candida albicans. Overexpression of CDR1, CDR2, and CaMDR1 has been reported contributing to azole resistance in C. albicans. In this study, hyper-resistant C. albicans mutant, with the above three genes deleted, was obtained by exposure to fluconazole and fluphenezine for 28...
Over the past two decades, the incidence of infections due to Candida glabrata, a yeast with intrinsic low susceptibility to azole antifungals, has increased markedly. Respiratory deficiency due to mutations in mitochondrial DNA (mtDNA) associated with resistance to azoles frequently occurs in vitro in this species. In order to specify the relationships between respiration and azole susceptibil...
background and purpose: actinomycetes have been discovered as source of antifungal compounds that are currently in clinical use. invasive aspergillosis (ia) due to aspergillus fumigatus has been identified as individual drug-resistant aspergillus spp. to be an emerging pathogen opportunities a global scale. this paper described the antifungal activity of one terrestrial actinomycete against the...
Some nitrogen-containing heterocycles can form both anionic (with abstraction of the N -H proton) and cationic derivatives (with addition of the proton to the pyridinic nitrogen atom). These include, in par ticular, 3,5-dichloro-l,2,4-triazole and 4,5-dichloro-2methylimidazole. These compounds were studied by 35C1 NQR spectroscopy [1,2]. Quantum-chemical analyses of the electronic structure of...
Management of fungal infections is complex with increasing choice of antifungals. Mortality and morbidity are significant despite treatment. Azoles are commonly used compounds which inhibit fungal lanosterol 14 demethylase, thereby depleting ergosterol in the fungal cell membrane with the accumulation of lanosterol precursors. Imidazoles (miconazole, ketoconazole, clotrimazole) are used in topi...
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