نتایج جستجو برای: azoles

تعداد نتایج: 1992  

Journal: :Biochemical and biophysical research communications 2008
Xin-Ming Jia Zhi-Ping Ma Yu Jia Ping-Hui Gao Jun-Dong Zhang Yan Wang Yong-Gang Xu Lin Wang Ying-Ying Cao Yong-Bing Cao Li-Xin Zhang Yuan-Ying Jiang

Widespread and repeated use of azoles, particularly fluconazole, has led to the rapid development of azole resistance in Candida albicans. Overexpression of CDR1, CDR2, and CaMDR1 has been reported contributing to azole resistance in C. albicans. In this study, hyper-resistant C. albicans mutant, with the above three genes deleted, was obtained by exposure to fluconazole and fluphenezine for 28...

Journal: :Antimicrobial agents and chemotherapy 2003
Sophie Brun Christophe Aubry Osana Lima Robert Filmon Thierry Bergès Dominique Chabasse Jean-Philippe Bouchara

Over the past two decades, the incidence of infections due to Candida glabrata, a yeast with intrinsic low susceptibility to azole antifungals, has increased markedly. Respiratory deficiency due to mutations in mitochondrial DNA (mtDNA) associated with resistance to azoles frequently occurs in vitro in this species. In order to specify the relationships between respiration and azole susceptibil...

Journal: :current medical mycology 0
s hadizadeh department of medical mycology & parasitology, faculty of medicine, kerman university of medical sciences, kerman, iran h forootanfar herbal and traditional medicines research center, kerman university of medical sciences, kerman, iran gh shahidi bonjar department of plant pathology & biotechnology, college of agriculture, bahonar university of kerman, iran m falahati nejad student research committee, mazandaran university of medical sciences, sari, iran a karamy robati department of medical mycology & parasitology, faculty of medicine, kerman university of medical sciences, kerman, iran sa ayatollahi mousavi department of medical mycology & parasitology, faculty of medicine, kerman university of medical sciences, kerman, iran

background and purpose: actinomycetes have been discovered as source of antifungal compounds that are currently in clinical use. invasive aspergillosis (ia) due to aspergillus fumigatus has been identified as individual drug-resistant aspergillus spp. to be an emerging pathogen opportunities a global scale. this paper described the antifungal activity of one terrestrial actinomycete against the...

Journal: :Current Fungal Infection Reports 2008

Journal: :Journal of the Korean Chemical Society 2004

2013
G. V. Dolgushin I. M. Lazarev L. I. Larina V. A. Lopyrev M. G. Voronkov

Some nitrogen-containing heterocycles can form both anionic (with abstraction of the N -H proton) and cationic derivatives (with addition of the proton to the pyridinic nitrogen atom). These include, in par­ ticular, 3,5-dichloro-l,2,4-triazole and 4,5-dichloro-2methylimidazole. These compounds were studied by 35C1 NQR spectroscopy [1,2]. Quantum-chemical analyses of the electronic structure of...

Journal: :The Indian journal of chest diseases & allied sciences 2015
Rajinder Singh Bedi

2017
Roger J.M. Brüggemann Jan-Willem C. Alffenaar Eliane M. Billaud Paul E. Verweij David M. Burger

Journal: :The Pediatric infectious disease journal 2011
Christopher C Blyth

Management of fungal infections is complex with increasing choice of antifungals. Mortality and morbidity are significant despite treatment. Azoles are commonly used compounds which inhibit fungal lanosterol 14 demethylase, thereby depleting ergosterol in the fungal cell membrane with the accumulation of lanosterol precursors. Imidazoles (miconazole, ketoconazole, clotrimazole) are used in topi...

Journal: :Clinical Infectious Diseases 1996

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