Abstract Herein, we present a novel approach for various asymmetric transformations of cyclic enones. The combination readily accessible chiral diamines and sterically demanding flexible phosphoric acids resulted in simple highly tunable catalyst framework. careful optimization the components led to identification particularly powerful multi‐purpose organocatalyst, which was successfully applie...

In this article, recyclable Fe3O4@SiO2@FeCl3 was synthesized and entirely characterized by various techniques including XRD, FT-IR, SEM, EDX and VSM analysis. The catalytic ability of produced Fe3O4@SiO2@FeCl3 was studied in the aza-Michael reaction of diethyl amine and ethyl crotonate which lead to high yie...

A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of an isoindoline-annulat-ed, tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy, is reported. This sequence involves a Heck reaction on vi-nylsulfonamides with batch microwave heating followed by a one-pot, sequential intramolecular aza-Michael cyclization/Boc-deprot-ection using MACOS...

This study highlights the potential of ?-hydroxy amines as building blocks for aza-Michael CANs.

A new asymmetric organocatalyzed intramolecular aza-Michael reaction by means of both a chiral auxiliary and a catalyst for stereocontrol is reported for the synthesis of optically active isoindolinones. A selected cinchoninium salt was used as phase-transfer catalyst in combination with a chiral nucleophile, a Michael acceptor and a base to provide 3-substituted isoindolinones in good yields a...

Herein, an asymmetric organocatalytic aza-Michael addition reaction of ketimines to nitroolefins is presented. The use 2-hydroxybenzophenone imine improves the enantioselective N-centered nucleophiles nitroalkenes by means intramolecular hydrogen bond formation at moiety. Moreover, versatility process demonstrated under both batch and flow conditions, showing synthesis a large variety nitroamin...