Transecting the axons of neurons in the adult superior cervical ganglion (SCG; axotomy) results in the survival of most postganglionic neurons, the influx of circulating monocytes, proliferation of satellite cells, and changes in neuronal gene expression. In contrast, transecting the afferent input to the SCG (decentralization) results in nerve terminal degeneration and elicits a different patt...

Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons. J. Neurophysiol. 78: 2790-2794, 1997. To better understand the neuronal mechanism of neuropathic pain, the effect of axotomy on the excitability of dorsal root ganglion (DRG) cells with unmyelinated axons (C cells) was investigated. Whole cell patch-clamp recordings were performed on intact DRG cells with ...

Following sciatic nerve transection in adult rats, a proportion o f injured dorsal root ganglion (DRG) neurons die, through apoptosis, over the following 6 months. Axotomy also has effects on expression of neurotrophins (NGF, BDNF, and NT-3) and their receptors (trkA, trkB, trkC, and p75NTR) in DRG as shown by in situ hybridisation or Northern blotting. Previous groups showed that administratio...

In the peripheral nervous system (PNS), root avulsion causes motoneuron degeneration, but the majority of motoneurons can survive axotomy. In order to study the mechanism of motoneuron degeneration, we compared the expression patterns of c-jun and neuronal nitric oxide synthase (nNOS), the well-known molecular players in PNS regeneration and degeneration, among adult rats having undergone axoto...

The electrical properties of cat medial gastrocnemius (MG) spinal motoneurons were studied 14-21 d following injection of type A botulinum toxin (BTX) into the MG muscle. Treated MG muscles were atrophic, displayed pronounced fibrillation activity, and were markedly but not completely paralyzed. MG motoneuron electrical properties from animals with the highest MG muscle-twitch forces (greater t...

introduction: neurotrophins belong to growth factor family and their function is based on their receptors. they bind two types of receptors: p75 and tyrosine kinase. the motoneuron survival or death depends upon the neurotrophic factors. recent studies have demonstrated that axotomy in peripheral nerve induces apoptosis of motoneuron. deprenyl or selegiline is known as a drug with neuroprotecti...

Nerve Injury In article 2200227, Jingwei Xie and co-workers summarize the recent advances in microfluidic nerve injury models, which enable scientists to test various hypotheses regeneration mechanisms. Representative device designs techniques, such as vacuum-assisted axotomy, compression or tension-based physical injury, laser-based chemical are described discussed.

Uninjured C-type rat dorsal root ganglion (DRG) neurons predominantly express slowly inactivating TTX-resistant (TTX-R) and slowly repriming TTX-sensitive (TTX-S) Na(+) currents. After peripheral axotomy, TTX-R current density is reduced and rapidly repriming TTX-S currents emerge and predominate. The change in TTX-S repriming kinetics is paralleled by an increase in the level of transcripts an...

background and objective: as apoptotic cell death is extremely involved in physiological development and many pathological situations such as cancer and neurodegenerative diseases, the understanding of its molecular machinery can be useful in designing new therapeutic strategies. the present study investigated the temporal expression of the proapoptotic protein bax in adult spinal motoneurons. ...

The effect of axotomy on the expression of the 57 kDa neuronal intermediate filament (IF) protein in adult rat dorsal root ganglion (DRG) neurons was examined. This IF protein is known to have an exclusively neuronal localization but is considerably more limited in its distribution in the nervous system than the neurofilament (NF) triplet proteins. The 57 kDa neuronal IF protein is similar (and...