نتایج جستجو برای: avidity
تعداد نتایج: 3485 فیلتر نتایج به سال:
زمینه و هدف: توکسوپلاسماگوندی(Toxoplasma gondii) عامل توکسوپلاسموز، تک یاخته ای است درون سلولی اجباری که قدرت آلوده کردن اکثر مهره داران خونگرم را دارد. چنانچه مادری در حین بارداری به عفونت مبتلا شود، ممکن است انگل پس از عبور از جفت لطمات و آسیب‌های مختلفی را بر جنین وارد کند. هدف از انجام این مطالعه، بررسی مقایسه ای روش‌های سرولوژیک اندازه گیریIgG و IgM ضد انگل در مادران باردار، و همچنین آزمای...
The parasite Toxoplasma gondii might harm the fetus if a woman is infected during pregnancy. IgG seroconversion and significant increase in IgG antibody amount in pregnancy indicates maternal infection. Presence of toxoplasma immunoglobulin M (IgM), immunoglobulin G (IgG) and low IgG avidity in a single serum sample indicates possible maternal infection, but positive toxoplasma IgM and low IgG ...
A major barrier to vaccines in cancer treatment is their failure to activate and maintain a complete cancer-specific CD8(+) effector T-cell repertoire. Low-avidity T cells are more likely to escape clonal deletion in the thymus when compared with high-avidity T cells, and therefore comprise the major population of effector T cells available for activation in patients with cancer. However, low-a...
Cells binding DNP groups conjugated to fluoresceinated mouse gamma globulin ((F)DNP-MGG) were isolated from spleens of unprimed mice using a fluorescence-activated cell sorter (FACS). The isolated cells were specifically enriched at least 100-fold for anti-DNP precursor activity in an adoptive transfer assay as compared to unfractionated spleen. The fraction depleted of binding cells, although ...
Dear Editor: At reviews in my research field, faced to an article published in your journal in Volume 20, Number 106, April 2013 titled "avidity ELISA method in the diagnosis of congenital toxoplasmosis", with interest all looked at it and found we had vague hints as to help promote your Journal referred to them. As you know, the purpose of this study was to determine the prevalence P...
We describe the avidity maturation of IgGs in human toxoplasmosis using sequential serum samples from accidental and natural infections. In accidental cases, avidity increased continuously throughout infection while naturally infected patients showed a different profile. Twenty-five percent of sera from chronic patients having specific IgM positive results could be appropriately classified usin...
BACKGROUND A limiting antigen avidity enzyme immunoassay (HIV-1 LAg-Avidity assay) was recently developed for cross-sectional HIV incidence estimation. We evaluated the performance of the LAg-Avidity assay alone and in multi-assay algorithms (MAAs) that included other biomarkers. METHODS AND FINDINGS Performance of testing algorithms was evaluated using 2,282 samples from individuals in the U...
Background and purpose: One of the transmission ways of the congenital toxoplasmosis is through the placenta to the fetus, therefore, its diagnosis at early stage is very important. Toxoplasma gondii parasite contains various antigens of which excretory-secretory antigens (E/SA) are used in designing Elisa avidity kit. The aim of this study was to compare the results of commercial kit and desig...
BACKGROUND Cancer vaccines are designed to activate and enhance cancer-antigen-targeted T cells that are suppressed through multiple mechanisms of immune tolerance in cancer-bearing hosts. T regulatory cell (Treg) suppression of tumor-specific T cells is one barrier to effective immunization. A second mechanism is the deletion of high avidity tumor-specific T cells, which leaves a less effectiv...
Traditional serological techniques have some limitations in evaluating the duration of Toxoplasma gondii infection in pregnant women, patients with lymphadenopathy, and older children suspected of having congenital toxoplasmosis. In these three groups of patients, two variants of T. gondii immunoglobulin G (IgG) avidity tests were used: an EIA Kit (Labsystems) and a noncommercial enzyme-linked ...
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