Purpose: The prognosis of melanoma depends on early diagnosis and timely treatment. Autophagy plays a dual role in tumor progression. In the stages, it prevents formation, while advanced stages promotes tumorigenicity. This study aimed at investigating autophagy different evaluating relationship between clinicopathological factors. Methods: ATG5 BECN1 genes expression tumors were evaluated retr...

Cigarette smoking is growing and nicotine is considered as the most adverse agent in the cigarette smoking. Nicotine is an alkaloid and forms 90% of alkaloids of cigarette. Nicotine is accountable for creating disorders and cancers such as lung cancer, heart disease and chronic lung disease. Nicotine can be considered as an autophagy and apoptosis inducer which can either directly or indirectly...

Introduction: Although exercise training and herbs consumption have protective effects on many diseases, the mechanism of action of exercise training with different intensities and citrus aurantium (CA) extract consumption on the autophagy-dependent MyoD activation pathway is not yet known. The aim of this study was to investigate the effect of eight weeks of moderate intensity continuous train...

Hair shafts are formed by terminal differentiation of hair keratinocytes which synthesize and cross-link keratins keratin-associated proteins. Here we tested the hypothesis that maturation also involves coordinated degradation non-cytoskeletal proteins autophagy. To this end, deleted essential autophagy regulator Atg7 in epidermis skin appendages, including hair, determined proteome from fully ...

Objective(s): Glioblastoma multiforme (GBM) is one of the most lethal forms of human cancer and temozolomide (TMZ) is currently part of the standard treatment for this disease. Combination therapy using natural substances can enhance the anti-cancer activity of TMZ. The purpose of this study was to evaluate the effect of TMZ in combination with thymoquinone (TQ) on human GBM cell line (U87MG). ...

Background: There is a growing interest in development of an effective adjuvant system for improving DNA vaccines. Recent findings have confirmed an important role for autophagy in both innate and adaptive immunity. The current study was undertaken to determine the efficacy of autophagy induction with Beclin-1, as a novel adjuvant system, in mice immunized with human papilloma virus (HPV) DNA v...

Objective(s): Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of eupafolin on LPS-induced cardiomyocyte autophagy...

Vitamin D deficiency has a role in IBD pathogenesis, and although the mechanisms surrounding its remain unclear, it been suggested that autophagy dysregulation is involved. Here, we show increased ileal expression of autophagy-suppressing miR-142-3p mice were fed vitamin D-deficient diet “involved” colonic biopsies from pediatric patients with low D. serves as potential mechanism mediating redu...

It has been proposed that appearance of amyloid beta (Aβ) in hippocampus is one of the characteristic features of Alzheimer’s disease (AD). The role of Nitric oxide (NO) in neurodegenerative disorders is controversy in different contexts. Here, we examined the effect of NO on spatial memory. For this purpose, we compared the effects of three different concentrations of L-NG-Nitroarginine Methyl...