نتایج جستجو برای: autoantibody

تعداد نتایج: 6541  

Journal: :Deutsches Aerzteblatt Online 2018

2011
Sharon A. Chung Kimberly E. Taylor Robert R. Graham Joanne Nititham Annette T. Lee Ward A. Ortmann Chaim O. Jacob Marta E. Alarcón-Riquelme Betty P. Tsao John B. Harley Patrick M. Gaffney Kathy L. Moser Michelle Petri F. Yesim Demirci M. Ilyas Kamboh Susan Manzi Peter K. Gregersen Carl D. Langefeld Timothy W. Behrens Lindsey A. Criswell

Systemic lupus erythematosus (SLE) is a clinically heterogeneous, systemic autoimmune disease characterized by autoantibody formation. Previously published genome-wide association studies (GWAS) have investigated SLE as a single phenotype. Therefore, we conducted a GWAS to identify genetic factors associated with anti-dsDNA autoantibody production, a SLE-related autoantibody with diagnostic and...

2015
Sharon A. Chung Joanne Nititham Emon Elboudwarej Hong L. Quach Kimberly E. Taylor Lisa F. Barcellos Lindsey A. Criswell Jose Crispin

Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies associated with specific clinical manifestations. Previous studies have shown an association between differential DNA methylation and SLE susceptibility, but have not investigated SLE-related autoantibodies. Our goal was to determine whether DNA methylation is associated with production of clinically releva...

Journal: :BMC Infectious Diseases 2021

Abstract Background Talaromyces marneffei ( T. marneffei) infection has been associated with adult-onset immunodeficiency due to anti-IFN-γ autoantibodies. We aimed investigate the clinical features of non-HIV-infected patients in southern China. Methods Between January 2018 and September 2020, we enrolled who were HIV-negative (group TM, n = 42), including autoantibody-positive TMP, 22) autoan...

2018
Emma C. de Moel Veerle F. A. M. Derksen Gerrie Stoeken Leendert A. Trouw Holger Bang Robbert J. Goekoop Irene Speyer Tom W. J. Huizinga Cornelia F. Allaart René E. M. Toes Diane van der Woude

BACKGROUND The autoantibody profile of seropositive rheumatoid arthritis (RA) is very diverse and consists of various isotypes and antibodies to multiple post-translational modifications. It is yet unknown whether this varying breadth of the autoantibody profile is associated with treatment outcomes. Therefore, we investigated whether the composition of the autoantibody profile in RA, as a mark...

Journal: :journal of reproduction and infertility 0

introduction: recurrent abortion (ra) may be a consequence of aberrant expression of immunological factors during pregnancy. although the relative importance of immunological factors in human reproduction remains controversial, substantial evidence suggests that autoantibodies contribute to reproductive failure. production of such antibodies is under the control of cytokines; and leptin, beside...

Journal: :journal of research in medical sciences 0
mansoor karimifar iman sharifi katayoun shafiey

background: diagnosis and treatment of neuropsychiatric lupus is still a major challenge in clinical practice. we investigated the association between depression and anti-ribosomal p (anti-p) antibodies in a sample of iranian patients with systemic lupus erythematosus (sle). materials and methods: th is cross-sectional study was conducted on adult patients with sle referring to a referral out-p...

Journal: :Journal of immunology 2000
Y Tsujihata T So Y Chijiiwa Y Hashimoto M Hirata T Ueda T Imoto

Self proteins including foreign T cell epitope induce autoantibodies. We evaluated the relationship between the size of foreign Ag introduced into self protein and the magnitude of autoantibody production. Mouse lysozyme (ML) was used as a model self protein, and we prepared three different ML derivatives carrying T cell epitope of hen egg white lysozyme (HEL) 107-116, i.e, heterodimer of ML an...

2013
Jorma Ilonen Anna Hammais Antti-Pekka Laine Johanna Lempainen Outi Vaarala Riitta Veijola Olli Simell Mikael Knip

We analyzed demographic and genetic differences between children with various diabetes-associated autoantibodies reflecting the autoimmune process. In a prospective birth cohort comprising children with HLA-conferred susceptibility to type 1 diabetes (T1D), the pattern of autoantibody appearance was analyzed in 520 children with advanced β-cell autoimmunity associated with high risk for disease...

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