introduction mycobacterium tuberculosis (mtb) is one of the most common causes of disseminated granulomatous diseases especially in developing countries. case presentation we present a patient who had an unusual type of tuberculosis who was misdiagnosed with some other common diseases such as infective endocarditis and collagen vascular diseases. pathological examination helped us to make decis...

background: vitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches. the exact etiology and pathogenesis of vitiligo is not clear. many theories have been presented regarding this subject among them aautoimmune theory is the most important one. the association of vitiligo with other autoimmune disorders has been reported, but the relationship ...

a 62-year-old woman complaining of severe malabsorption was diagnosed with celiac disease based on the findings of flat, small intestinal mucosa and hla-dq2 positivity, although celiac serology was negative. this diagnosis was questioned due to the lack of clinical and histological improvement after a long period of strict gluten-free diet. the detection of enterocyte autoantibodies guided to t...

Objective Autoantibodies have been reported to be associated with cancers. As a biomarker, autoantibodies widely used in the early screening of lung cancer. However, correlation between and prognosis cancer patients is poorly understood, especially Asian population. This retrospective study investigated association presence outcomes Methods A total 264 diagnosed were tested for Henan Provincial...

INTRODUCTION BRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known to be implicated in the production of pro-inflammatory cytokines.We have observed that sera from rheumatoid arthritis (RA) patients recognize the BRAF's catalytic domain, which encompasses amino acids 416 to 766. Here...

Autoimmune hepatitis is a chronic hepatitis that occurs in children and adults of all ages. Diagnosis is based upon characteristic serologic and histologic findings and the exclusion of other forms of chronic liver disease. Guidelines issued by the AASLD suggest the following diagnostic considerations: The diagnosis should be made in patients with compatible clinical signs, symptoms, and labora...