auraptene

mahdi askari department of pharmacognosy, biotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran amirhossein sahebkar department of pharmacognosy, biotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran mehrdad iranshahi department of pharmacognosy, biotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s) 7-prenyloxycoumarins including 7-isopentenyloxycoumarin, auraptene and umbelliprenin, and herniarin have been widely recognized as bioactive coumarins. this paper presents the ways to synthesis these compounds. materials and methods 7-prenyloxycoumarins were synthesized by reaction between 7-hydroxycoumarin (' m) and relevant prenyl bromides (1.5 m) in acetone at room temperat...

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Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson’s Disease

2016

Satoshi Okuyama Tomoki Semba Nobuki Toyoda Francesco Epifano Salvatore Genovese Serena Fiorito Vito Alessandro Taddeo Atsushi Sawamoto Mitsunari Nakajima Yoshiko Furukawa

In patients with Parkinson's disease (PD), hyperactivated inflammation in the brain, particularly microglial hyperactivation in the substantia nigra (SN), is reported to be one of the triggers for the delayed loss of dopaminergic neurons and sequential motor functional impairments. We previously reported that (1) auraptene (AUR), a natural prenyloxycoumain, suppressed inflammatory responses inc...

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