The Au nanoparticle (AuNPs) and DNA oligonucleotide conjugates will have complicated microstructures because one AuNP can be conjugated to more than one single-stranded DNA (ssDNA) on its surface. In this paper, the AuNPs-DNA conjugates with controllable microstructure were prepared on SiO2 microsphere carriers. The reactions between AuNPs with ssDNA on SiO2 carriers were sterically restricted ...

Therapeutic uses of DNA functionalized gold nanoparticles (DNA-AuNPs) have shown great potential and exciting opportunities for disease diagnostics and treatment. Maintaining stable conjugation between DNA oligonucleotides and gold nanoparticles under thermally stressed conditions is one of the critical aspects for any of the practical applications. We systematically studied the thermal stabili...

In recent years, assemblies of functionalised gold nanoparticles (AuNPs) have received a growing interest as a route toward hybrid materials with new functionalities. Here, we report on thermally reversible assemblies formed by mixing thermosensitive polymerprotected AuNPs and Pluronic triblock copolymers. Amino-terminated copolymers, poly(EO-st-PO), with different EO/PO ratios were coupled by ...

Cetuximab (C225) is a unique agent, targeting epidermal growth factor receptor (EGFR)-positive cancer. However, the therapeutic effect of C225 in EGFR high-expressing non-small cell lung cancer (NSCLC) remains poor. Here, we report that conjugation of C225 with gold nanoparticles (AuNPs) enhances the cytotoxicity of C225 in NSCLC both in vitro and in vivo. The NSCLC cell lines A549 (EGFR(high))...

Electrochemical and in situ spectroelectrochemical behaviours of phenosafranine (PS + ) were studied at the gold nanoparticles (AuNps) immobilized Nafion (Nf) film coated glassy carbon (GC) and indium tin oxide (ITO) electrodes. Cyclic voltammetric studies showed that the PS + molecules strongly interact with the AuNps immobilized in the Nf matrix through the electrostatic interaction. The pres...

Section 2 FT-IR spectra of the NG/AuNPs, NG/AuNPs/FDH and NG/AuNPs/laccase Section 3 Control experiments at different electrode. Section 4 CV of the formic acid oxidation Section 5 Polarization curves of the NG/AuNPs/FDH electrode and G/AuNPs/FDH electrode Section 6 Crossover between the bioanode and biocathode Section 7 Dependence of power density on the formic acid concentration for EBFC Sect...

Targeting of G-protein coupled receptors (GPCRs) like somatostatin-14 (SST-14) could have a potential interest in delivery of anti-cancer agents to tumor cells. Attachment of SST to different nano-carriers e.g. polymeric nanoparticles is limited due to the difficulty of interaction between SST itself and those nano-carriers. Furthermore, the instability problems associated with the final formul...

A sensitive electrochemical sensor was fabricated for selective detection of nitric oxide (NO) based on electrochemically reduced graphene (ErGO)-polyaniline (PANI)-gold nanoparticles (AuNPs) nanocomposite. It was coated on a gold (Au) electrode through stepwise electrodeposition to form AuNPs-PANI-ErGO/Au electrode. The AuNPs-PANI-rGO nanocomposite was characterized by Field Emission Scanning ...

Polymer-stabilized gold nanoparticles (AuNPs) were prepared and encoded with a range of surface-enhanced Raman reporter molecules. A range of as-synthesized polymers produced by reversible addition fragmentation chain transfer (RAFT) polymerization were demonstrated to self-assemble at the surface of AuNPs dispersed in water. The method involved the coprecipitation of polymer-gold conjugates by...

A highly sensitive self-powered humidity sensor has been realized from AuNPs hybrid black zinc oxide (ZnO) nanorods prepared through a sol-gel method. XRD pattern reveals that both ZnO and ZnO/AuNPs exhibit a wurtzite structure. ZnO/AuNPs nanorods grow in a vertical alignment, which possesses high uniformity and forms dense arrays with a smaller diameter than that of ZnO nanoparticles. All ZnO/...