Iron is critical in multiple aspects of CNS development, but its role in neurodevelopment--the ability of iron deficiency to alter normal development--is difficult to dissociate from the effects of anemia. We developed a novel dietary restriction model in the rat that allows us to study the effects of iron deficiency in the absence of severe anemia. Using a combination of auditory brainstem res...

SOFT TISSUE RECONSTRUCTION of the conchal aspects of the external ear includes a variety of approaches, including granulation, graft, or local skin flap. We describe our experience with the single-stage subcutaneous island pedicle graft (flip-flop) flap for reconstruction of defects with a significant amount of exposed cartilage involving primarily the concha, antitragus, antihelix, and externa...

A. 1981. Attraction of zebrafish, Brachydanio rerio to isolated and partially purified chromatographic fractions. Enivron. Baier, H. 2000. Zebrafish on the move: towards a behavior-genetic analysis of vertebrate vision. behavioral screening method for detecting auditory response defects in zebrafish. An increase in habitat complexity reduces aggression and monopolization of food by zebra fish (...

Sorting nexins are a large family of evolutionarily conserved proteins that play fundamental roles in endocytosis, endosomal sorting and signaling. As an important member of sorting nexin family, sorting nexin 9 (SNX9) has been shown to participate in coordinating actin polymerization with membrane tubulation and vesicle formation. We previously showed that SNX9 is expressed in mouse auditory h...

background :older adults with cerebrovascular accident (cva) show evidence of auditory and speech perception problems. in present study, it was examined whether these problems are due to impairments of concurrent auditory segregation procedure which is the basic level of auditory scene analysis and auditory organization in auditory scenes with competing sounds. methods : concurrent auditory seg...

Much like vertebrate hair cells, the chordotonal sensory neurons that mediate hearing in Drosophila are motile and amplify the mechanical input of the ear. Because the neurons bear mechanosensory primary cilia whose microtubule axonemes display dynein arms, we hypothesized that their motility is powered by dyneins. Here, we describe two axonemal dynein proteins that are required for Drosophila ...

Hearing is one of the last sensory modalities to be subjected to genetic analysis in Drosophila melanogaster. We describe a behavioral assay for auditory function involving courtship among groups of males triggered by the pulse component of the courtship song. In a mutagenesis screen for mutations that disrupt the auditory response, we have recovered 15 mutations that either reduce or abolish t...