Introduction To determine the clinical significance of anti-CCP (anticitrullinated cyclic peptide) in Korean patients with JRA. Rheumatoid Factor (RF) is a non-specific serologic test in juvenile rheumatoid arthritis (JRA) but the anti-perinuclear autoantibodies are found in adult rheumatoid arthritis (RA) recently. One of these autoantibodies can detect epitopes called citrulline. The authors ...

Background: Several antibodies, also called serological markers, are associated with specifi c forms, disease behavior and phenotype of infl ammatory bowel disease (IBD). Aim: Summarize and analyze the evidence of the utility of serologic markers in IBD, making emphasis on their clinical utility and behavior between populations. Material and methods: Relevant articles were located by computer-a...

  Introduction: Development of effective immunodiagnostic methods for detection of Mycobacterium tuberculosis infection is crucial. Serodiagnostic methods, based on antibody response to specific antigens could provide promising approaches for rapid, economical and easy to perform diagnostic tests which are crucial for tuberculosis (TB) control. In this study, the level of IgG antibody responses...

Antibodies to citrullinated peptides are highly specific for rheumatoid arthritis (RA) and represent a significant risk factor for undifferentiated polyarthritis. This prognostic ability may be related to the very diagnostic performance of these autoantibodies, since RA is a more erosive disease than other forms of arthritis. The present study evaluated an association of antibodies to citrullin...

Anti-neutrophil antibodies have been shown in sera from patients with a variety of inflammatory diseases. Those reacting with components of neutrophil cytoplasm are associated with systemic vasculitis. Both nuclear and perinuclear staining patterns on human neutrophils have been reported using sera from patients with inflammatory bowel disease. We have evaluated the reactivity against human neu...

a-Amylase was localized in aleurone cells of barley using immunohistochemical methods. Anti-a-amylase antibody was produced by rabbits immunized with enzyme purified from malt diastase and Himalaya variety barley seeds. Immunoelectrophoresis showed that the antibodies to both antigens were immunologically similar, therefore, they were used interchangeably in the localization of a-amylase. Fluor...

BACKGROUND The "International consensus statement on testing and reporting antineutrophil cytoplasmic antibodies (ANCA)" advocates screening by indirect immunofluorescence (IIF), but external quality assessment programmes often demonstrate different IIF patterns for a single serum. AIM To determine whether the variation in IIF patterns can be attributed solely to errors in interpretation. M...

BACKGROUND & AIMS To determine the prognostic potential of classic and novel serologic antibodies regarding unfavorable disease course in a prospective ulcerative colitis (UC) patient cohort, since few and conflicting data are available in the literature regarding this matter. METHODS 187 consecutive patients were studied prospectively (median follow-up: 135 months) from a single referral IBD...