Treatment for patients with stage IV indolent lymphoma ranges from watchful waiting to intensive chemotherapy and stem cell transplantation. In this trial we compared 2 induction regimens followed by 1 year of interferon maintenance therapy. Fludarabine, mitoxantrone (Novantrone), and dexamethasone (FND) were compared with an alternating triple therapy (ATT) regimen (CHOD-Bleo, ESHAP, and NOPP)...

I have done my master thesis project on autonomic computing at Amadeus, a major provider of online travel booking systems. Autonomic computing is an effort to decrease the cost of owning an IT infrastructure through self-management of systems. The approach is to develop an infrastructure for an external autonomic manager which can interact with legacy systems. This infrastructure is implemented...

Background. Despite the dramatic scale-up of antiretroviral therapy in low- and middle-income countries, tuberculosis (TB) is still the main cause of death among HIV-infected patients in resource-limited settings. Previous studies in patients with TB meningitis suggest that the use of higher doses of common anti-TB drugs could reduce mortality. Methods. Using clinical data from an HIV cohort st...

We report a case of paradoxical worsening of tuberculous chorioretinitis after initiation of anti-tuberculous therapy (ATT). The patient had left panuveitis with tuberculous chorioretinitis and was started on systemic ATT and oral steroids a week later. However, he developed paradoxical worsening 2 months after initiation of therapy. He was continued on ATT, oral steroids and intravitreal amika...

Tuberculosis is a common opportunistic infection and a leading cause of death in HIV patients worldwide, especially in developing countries. The study was conducted to evaluate the relation of CD4 counts to occurrence and type of TB and to observe for the recovery of CD4 counts after treatment for tuberculosis in patients of pulmonary tuberculosis and extra pulmonary tuberculosis. This retrospe...

An unprecedented combination of simula-tive and metaphor based reasoning about beliefs is achieved in an AI system, ATT-Meta. Much mundane discourse about beliefs productively uses conceptual metaphors such as MIND AS CONTAINER and IDEAS AS INTERNAL UTTERANCES, and ATT-Meta's metaphor-based reasoning accordingly leads to crucial discourse comprehension decisions. ATT-Meta's non-metaphorical mod...

In 1998 a new method to reduce the production of an optional protein in a cell was discovered, which enabled a new way of performing high throughput experiments. The effect of individual proteins on essential cell-properties could be analyzed by silencing one protein at a time. These experiments resulted in large quantities of data that had to be analyzed. In practice this was only possible if ...

UNLABELLED The endocarditis and biofilm-associated pili (Ebp) are important in Enterococcus faecalis pathogenesis, and the pilus tip, EbpA, has been shown to play a major role in pilus biogenesis, biofilm formation, and experimental infections. Based on in silico analyses, we previously predicted that ATT is the EbpA translational start codon, not the ATG codon, 120 bp downstream of ATT, which ...

Sjukhusrelaterade infektioner är en vanlig orsak till dödlighet och lidande runt om i världen. Ett allt större intresse har visats detta ämnesområde och WHO har påpekat vikten av att jobba med dessa frågor. Problemet är störst på sjukhusens intensivvårdsavdelningar där de sjukaste patienterna vårdas. Förekomsten av bakterier som är resistenta mot ett eller flera antibiotika är också störst på d...