Pharmacological cardioversion is still a fundamental and readily available instrument to control symptoms and promptly restore sinus rhythm in atrial fibrillation. A rapidly acting, efficacious and safe agent that targets the fibrillating atria without affecting ventricular refractoriness is highly desirable. Among newer atrial-selective antiarrhythmic agents, vernakalant is in the most advance...

Yaroslav M. Lohvinov, MD, PhD, is currently Assistant Professor at the Functional Diagnostics Department at the National P.L. Shupyk Medical Academy of Postgraduate Education, Kyiv, Ukraine, and Consultant Cardiologist at the Institute of Heart, Healthcare Ministry of Ukraine. In 2014 Doctor Lohvinov defended his PhD evaluating the structure and function of atria and their appendages in patient...

Atrial fibrillation is the most common type of tachyarrhythmia caused by multiple re-entrant wave forms within the atria and bombarding the atrioventricular node several times making it beat in a rapid, disorganized fashion termed "fibrillation". In atrial fibrillation, atria beat more than 300 times per minute. The arrhythmatous condition needs to be controlled, as humans cannot withstand this...

BACKGROUND Patients with atrial fibrillation (AF) at the highest stroke risk derive the largest benefit from oral anticoagulation (OAC). Those with the highest stroke risk have been paradoxically less likely to receive OAC. This study assessed the association between stroke and bleeding risk on rates of OAC. METHODS AND RESULTS We analyzed OAC use among 10,098 patients with AF from 174 commun...

BACKGROUND Normal development of the atria requires left-right differentiation during embryonic development. Reduced expression of Pitx2c (paired-like homeodomain transcription factor 2, isoform c), a key regulator of left-right asymmetry, has recently been linked to atrial fibrillation. We therefore systematically studied the molecular composition of left and right atrial tissue in adult murin...

Atrial fibrillation (AF) is the most common type of arrhythmia in general population with a prevalence that reaches one third patients arterial hypertension, diabetic and other risk factors. In atrial fibrillation, regular impulses produced by sinus node for normal heart beat are overwhelmed rapid electrical discharges atria adjacent parts pulmonary veins. Omega-3 polyunsaturated fatty acids (P...

We apply methods from non-linear statistical time series analysis to characterize electrograms of atrial fibrillation. These are based on concepts originating from the theory of non-linear dynamical systems and use the empirical reconstruction density in reconstructed phase space. Application of these methods is not restricted to deterministic chaos but is valid in a general time series context...

Aim: The ATRIA score was developed to assess the probability of an ischemic stroke in patients with atrial fibrillation (AF). modified (M-ATRIA) risk incorporates predictive variables for coronavirus disease 2019 (COVID-19). As a result, we looked into association between M-ATRIA and in-hospital death COVID-19 patients.Materials Methods: data 595 inpatients research were evaluated retrospective...

BACKGROUND The transition from persistent to permanent atrial fibrillation (AF) is associated with increased complexity of fibrillatory conduction. We have investigated the spatial distribution of fibrillation waves and structural alterations in the atrial free walls in a goat model of AF. METHODS AND RESULTS AF was maintained for 3 weeks (short term [ST], persistent AF) or 6 months (long ter...

Atrial fibrillation (AF) is already the most commonly occurring arrhythmia. Catheter pulmonary vein ablation has emerged as a treatment that is able to make the arrhythmia disappear; nevertheless, recurrence to arrhythmia is very frequent. In this study, it is proposed to perform an analysis of the electrical signals recorded from bipolar catheters at three locations, pulmonary veins and the ri...