OBJECTIVE To compare the effects of the angiotensin II antagonist, losartan, with those of atenolol on left ventricular hypertrophy (LVH), blood pressure and neurohormone concentrations in hypertensive patients with LVH. DESIGN A multinational, randomized, double-blind trial. SETTING Hospital. PATIENTS Hypertensive patients with an echocardiographically documented left ventricular mass in...

Effects of betaxolol, a cardioselective beta-adrenoceptor antagonist, on cardiohemodynamics and coronary circulation were investigated in two kinds of anesthetized open-chest dog preparations in comparison with those of atenolol and propranolol. When administered intravenously, betaxolol, atenolol and propranolol produced dose-dependent decreases in the heart rate (HR), maximum left ventricular...

the emerging contaminants are commonly derived from municipal, agricultural, and industrialwastewater sources and pathways. these compounds are polar and poorly biodegradable. the dynamicremoval of atenolol from aqueous solutions by activated carbon in fixed bed column systems was investigated. as far as we know, this is the first study reporting the decontamination by adsorption in fixed bed o...

introduction broiler chickens are intensively selected for productive traits. the management of these highly productive animals must be optimal to allow their full genetic potential to be expressed. if this is not done, inefficient production and several metabolic diseases such as ascites become apparent. investigations in mammals indicated that the b- adrenoreceptor characteristics are differe...

OBJECTIVES We compared the effects of five pharmacologic regimens on the circadian rhythm and exercise-induced changes of ventricular rate (VR) in patients with chronic atrial fibrillation (CAF). BACKGROUND Systematic comparison of standardized drug regimens on 24 h VR control in CAF have not been reported. METHODS In 12 patients (11 male, 69+/-6 yr) with CAF, the effects on VR by 5 standar...

BACKGROUND A recent meta-analysis of drug effects in patients with hypertension claims that all beta-adrenergic blockers are equally effective but less so than other antihypertensive drugs. Published comparisons of the beta-adrenergic blocker atenolol and non-atenolol beta-adrenergic blockers indicate different effects on death rates, arrhythmias, peripheral vascular resistance and prognosis po...

OBJECTIVE To study the effects on myocardial ischaemia of 50 mg of atenolol, 20 mg of slow release nifedipine, and their fixed combination given 12 hourly. DESIGN A treadmill exercise test and 24 hour ambulatory electrocardiographic monitoring were carried out after a period of five days off treatment (control) and at the end of three weeks of each treatment period. PATIENTS 23 patients wit...

The antihypertensive effect of atenolol, a new beta-1-receptor blocking agent, was studied in a double-blind trial in which 45 patients with essential hypertension were randomly assigned to placebo or atenolol treatment. Atenolol caused a statistically significant and clinically relevant reduction of blood pressure. The optimum daily dose for moderately severe hypertension was considered to be ...

It is possible to alter the permeability of ethyl cellulose membrane with certain materials such as surfactants. In this study the effect of surfactant concentration and different HLB values on the release rate of atenolol from ethyl cellulose-coated tablets was evaluated. The results showed that when the concentration of surfactant increased, the rate of drug release also increased. The kineti...

UNLABELLED INTRODUCTION Atenolol is commonly used by patients with hypertension, angina pectoris, or myocardial infarction. There have been reports of various adverse effects associated with the use of atenolol including bullous pemphigoid. To the best of our knowledge we present the first case report of atenolol-induced mucous membrane pemphigoid. CASE PRESENTATION A 42-year-old Thai man ...