Single conical nanopores in polymer foils are fabricated by means of the ion track etching technique. They are chemically modified so that they selectively react with certain molecules to be analyzed. This specific reaction is electrochemically monitored by measuring the electrolyte current flowing through the nanopores in an electrochemical cell. This current is dependent on the presence and c...

Atomically thin materials, and in particular graphene, provide a new class of solid-state nanopores-apertures that allow for the exchange of matter across thin membranes-with the smallest possible volumes of any ion channel. As the diameter of these nanopores becomes comparable to that of hydrated ions, sub-continuum effects have the potential to enable selective transport similar to that obser...

Currently, researchers are deeply involved in the field of nanopore technology due to its wide range of applications. Nanopores have been used for the detection and analysis of a variety of analytes, proteins, small organic molecules and metal ions [1-2]. So it becomes crucial to modify the chemistry of the nanopore walls to achieve desired interactions with molecules of interest. Single conica...

It has been demonstrated that cone-shaped nanopores with charged surfaces are cation selective, and, for the same magnitude of applied voltage, show preferential cation flow from the narrow entrance to the wide opening of the cone [1]. Presently, there are two models which describe this nonlinear current-voltage characteristic seen in polymer nanopores. The first model focuses on the presence o...

Solid-state nanopores have emerged as versatile single-molecule sensors for applications including DNA sequencing, protein unfolding, micro-RNA detection, label-free detection of single nucleotide polymorphisms, and mapping of DNA-binding proteins involved in homologous recombination. While machining nanopores in dielectric membranes provides nanometer-scale precision, the rigid silicon support...

The suitability of three vapor deposition techniques for pore size modification was evaluated using polycarbonate track etched membranes as model supports. A feature scale model was employed to predict the pore geometry after modification and the resulting pure water flux. Physical vapor deposition (PVD) and pulsed plasma-enhanced chemical vapor deposition (PECVD), naturally, form asymmetric na...

The presence of Cs+ ions in the pseudo-1D nanopores of zeolite ITQ-4, Si32O64, is confirmed by x-ray diffraction and atomic pair distribution function analysis. Inside the nanopores the Cs+ ions are found to assemble in zigzag chains and thus form an extended, positively charged sublattice providing charge balance for a low-density electron gas also confined to the nanopores.

Driving single nanoparticles like DNA and proteins by the electrophoretic force through a nanopore in the presence of an electric field produces an ionic current, which passes from the nanopore. The current blockage due to the nanoparticle translocation makes an observable change in the ionic current, which is useful for the study of bio molecules. Many efforts are made to perceive the electro ...

In the last two decades, new techniques that monitor ionic current modulations as single molecules pass through a nanoscale pore have enabled numerous single-molecule studies. While biological nanopores have recently shown the ability to resolve single nucleotides within individual DNA molecules, similar developments with solid-state nanopores have lagged, due to challenges both in fabricating ...