BACKGROUND Astragalus injection is used by practitioners of traditional Chinese medicine to treat diabetic nephropathy (DN). The current study was conducted to determine the effect of astragalus on tubular epithelial transdifferentiation during the progression of DN in KKAy mice, as well as to investigate the molecular mechanism underlying this effect. METHODS Diabetic, 14-week-old, male KKAy...

The objective of this research was to study the relationships between environmental factors and distribution of Astragalus verus and Astragalus glaucops in order to find the most effective factors in the distribution of Astragalus verus and Astragalus glaucops in west of Iran. Sampling of soil and Floristic composition were performed with Eco-phytosociology method. Floristic composition data in...

The present study was focused on improving the quality of rice koji by fermentation with a selected Aspergillus oryzae strain and a plant Astragalus radix. A. oryzae KCCM 60345 was used as main inoculant and the Astragalus radix was added as supplement in rice koji preparation. LC-MS based metabolite analysis and tyrosinase inhibitory activities were studied for different time periods. A. oryza...

Astragalus polysaccharide is a major component of radix astragali, a vital qi-reinforcing herb medicine with favorable immune-regulating effects. In a previous animal experiment, we demonstrated that astragalus polysaccharide effectively alleviates ischemia-reperfusion injury (IRI) of cardiac muscle through the regulation of the inflammatory reactions. However, the relationship between this her...

The protective effects of two Chinese herbs, astragalus mongholicus, polygonum multiflorum and astragalus mongholicus-polygonum multiflorum in combination against thymus injury induced by cyclophosphamide were evaluated by transmission electron microscopy, image analysis, DNA gel electrophoresis as well as flow cytometry. Results showed that mice pretreated with cyclophosphamide had degenerated...

Selenium-accumulator plants synthesize selenium compounds that differ from those produced by nonaccumulators. To determine if there are any subcellular differences between accumulators and nonaccumulators in the use of selenomethionine in vitro, polysomes from Astragalus crotalariae (accumulator) and Astragalus lentiginosis (nonaccumulator) were translated in the presence of selenomethionine. P...

Astragalus L. is a perennial herbaceous genus belonging to the family Fabaceae. Chromosome morphology was defined for the first time in four species of Astragalus namely; A. antalyensis A.Duran & Podlech, A. nezaketae A.Duran & Aytaç, A. cariensis Boiss. & A. schizopterus Boiss. All species contained diploid chromosome numbers of 2n = 16. However, polyploid cells (4x = 32) were also observed in...

Astragalus membranaceus is a famous Chinese medicinal herb. Polysaccharides are the most important functional constituent in Astragalus membranaceus. In the present study, the effects of Astragalus membranaceus polysaccharides (APS) on exercise endurance capacity were evaluated in mice using swimming exercise. The antioxidant properties of APS were also investigated through the 1,1diphenyl-2-pi...

Astragalus L., is one of the largest genus of flowering plants in the Leguminosae family. The aim of this study was to review anti-carcinoma activities of this valuable herb. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and Iran Medex databases .The initial search strategy identified about 128 references. In this study, 113 studies was accepted fo...

This study was conducted to evaluate the antimicrobial and antioxidant activities of the hexane and methanol extracts of the aboveground parts and roots of some Astragalus species grown in the vicinity of Erzurum, located in the eastern Anatolia, Turkey. The methanol extract, which was obtained from the aboveground parts of Astragalus species, exhibited mild free radical scavenging activity pro...