Abstract Some patients with severe asthma experience exacerbations despite receiving multiple therapy. The risk of exacerbation and heterogeneous response to treatment may be associated specific inflammatory molecules that are responsive or resistant corticosteroids. We aimed identify the independent factors predictive for future in asthma. In this multi-center prospective observational study, ...

BACKGROUND Early identification of the severity of asthma exacerbation would be helpful for the management of patients. We aimed to evaluate the correlation of morphological change in activated eosinophils and the severity of an asthma exacerbation. METHODS Blood was collected from 55 asthmatic children: 40 of whom were having an exacerbation, 15 symptom-free, and 15 healthy controls. The per...

OBJECTIVES Emergency department (ED) visits for asthma exacerbation reflect a failure of longitudinal asthma management. However, little is known about the characteristics of patients with frequent ED visits (≥2 visits in a 1-year period). We aimed to characterise the adult patients who frequently presented to the ED for asthma exacerbation in Japan. DESIGN A multicentre chart review study of...

INTRODUCTION Platelets play important roles in airway inflammation and are activated in inflammatory lung diseases, including asthma. AIM We evaluated the mean platelet volume (MPV), used as a marker of platelet activation, in asthmatic patients during asymptomatic periods and exacerbations compared to healthy controls to determine whether MPV can be used as an indicator of inflammation. MA...

BACKGROUND/AIMS Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and those with exacerbation of acute asthma. All subjects were young males. METHODS We measured VEGF ...

background: industrialization and urbanization had a devastating impact on public health and caused an increase in health related morbidity and mortality. in fact, asthma is a chronic condition which is considered as one of the significant challenges of public health. in this study, we investigated the association of air pollution and weather conditions with excess emergency ward admissions of ...

Adults with asthma who had been enrolled in an HMO for at least a year were requested to complete a questionnaire about their health status. Approximately 25% of the 1,461 participants responded positively to "Does your current work environment make your asthma worse?" and were classified as having workplace exacerbation of asthma. Those with workplace exacerbation were more likely to have neve...

BACKGROUND Upper respiratory tract infections (URIs) represent the most frequent cause of acute asthma exacerbation. Systemic corticosteroid (CS) is presently recommended for URI-induced asthma exacerbation, although it might inhibit cellular immunity against respiratory virus infection. OBJECTIVES To determine the effects of adding a short course (2 weeks) of a leukotriene receptor antagonis...

Despite asthma being the most common chronic childhood ailment, there is still much to learn about the disease. Early childhood infections with well-known or emerging viruses can lay the pathophysiologic framework for asthma development and exacerbation later in life, which may be due partly to alteration of the airway microbiome. Once asthma is established, acute exacerbations are usually asso...

Background: The prevalence of asthma varies among different regions based on the presence risk factors. Second-hand smoking is one factors that leads to an increased prevalence, exacerbation, and poor control asthma. Thereby, this study aimed investigate children impact second-hand patients. Methodology: This cross-sectional included parents in Saudi Arabia. It was conducted during period from...