نتایج جستجو برای: associated protein bap

تعداد نتایج: 2524810  

Journal: :Cancer research 2015
Andrew D Southam Farhat L Khanim Rachel E Hayden Julia K Constantinou Katarzyna M Koczula Robert H Michell Mark R Viant Mark T Drayson Chris M Bunce

The redeployed drug combination of bezafibrate and medroxyprogesterone acetate (designated BaP) has potent in vivo anticancer activity in acute myelogenous leukemia (AML) and endemic Burkitt lymphoma (eBL) patients; however, its mechanism-of-action is unclear. Given that elevated fatty acid biosynthesis is a hallmark of many cancers and that these drugs can affect lipid metabolism, we hypothesi...

Journal: :Carcinogenesis 2006
Petra A Tsuji Thomas Walle

Cigarette smoking is a major risk factor in lung carcinogenesis via carcinogens such as polycyclic aromatic hydrocarbons (PAHs) and nitrosamines. In this study, we used benzo[a]pyrene (BaP) as the classic PAH compound and BEAS-2B cells, a model of normal human bronchial epithelial cells, to investigate whether 5,7-dimethoxyflavone (5,7-DMF) and 3',4'-DMF compared with resveratrol (RV) have chem...

2018
Shanshan Lin Aiguo Ren Linlin Wang Yun Huang Yuanyuan Wang Caiyun Wang Nicholas Greene

Neural tube defects (NTDs) are among the most common and severe congenital malformations and result from incomplete closure of the neural tube during early development. Maternal exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested to be a risk factor for NTDs and previous studies imply that the mechanism underlying the association between PAH exposure and NTDs may involve oxid...

Journal: :Cancer research 1986
U Varanasi M Nishimoto W L Reichert B T Le Eberhart

Metabolism of benzo(a)pyrene (BaP) in vivo and in vitro was studied using two benthic fish species, English sole (Parophrys vetulus) and starry flounder (Platichthys stellatus), and Sprague-Dawley rats. At 24 h after administration of BaP (7.9 mumol/kg of body weight) to fish either p.o. (Experiment 1) or i.p. (Experiment 2), the specific activity of binding of BaP metabolites to hepatic DNA (p...

2015
Li-Juan Shi Jian-Jun Ou Jing-Bo Gong Su-Hong Wang Yuan-Yue Zhou Fu-Rong Zhu Xu-Dong Liu Jing-Ping Zhao Xue-Rong Luo

BACKGROUND Parents of children with autism have higher rates of broad autism phenotype (BAP) features than parents of typically developing children (TDC) in Western countries. This study was designed to examine the rate of BAP features in parents of children with autism and the relationship between parental BAP and the social impairment of their children in a Chinese sample. METHODS A total o...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2012
Po Ying Poon Hoi Hin Kwok Patrick Y K Yue Mildred S M Yang Nai Ki Mak Chris K C Wong Ricky N S Wong

Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon ubiquitously existing in the environment. Its metabolites have been shown to cause DNA damage and cellular dysfunction in humans. Panax ginseng C.A. Meyer is a Chinese medicinal herb, and ginsenosides are the main active constituent of ginseng. Accumulating evidence had indicated that ginseng extract and ginsenosides possess cytoprotecti...

2016
Mozhgan Derakhshan Sefidi Iraj Rasooli Parviz Owlia Daryush Talei Shakiba Darvish Alipour Astaneh Shahram Nazarian

AIM To study immunogenicity of Pseudomonas N terminal flagellin as an adjuvant for Acinetobacter baumannii (A. baumannii) biofilm associated protein (Bap). METHODS The N terminal flagellin gene was amplified. The pET28a (+) and polymerase chain reaction products were digested with HindIII and EcoR I. The ligation of N terminal flagellin into pET28a (‏+) was performed using T4 DNA ligase and w...

2016
Agustina Taglialegna Susanna Navarro Salvador Ventura James A. Garnett Steve Matthews José R. Penades Iñigo Lasa Jaione Valle

Biofilms are communities of bacteria that grow encased in an extracellular matrix that often contains proteins. The spatial organization and the molecular interactions between matrix scaffold proteins remain in most cases largely unknown. Here, we report that Bap protein of Staphylococcus aureus self-assembles into functional amyloid aggregates to build the biofilm matrix in response to environ...

2016
Jerry Campbell Allison Franzen Cynthia Van Landingham Michael Lumpkin Susan Crowell Clive Meredith Anne Loccisano Robinan Gentry Harvey Clewell

Benzo[a]pyrene (BaP) is a by-product of incomplete combustion of fossil fuels and plant/wood products, including tobacco. A physiologically based pharmacokinetic (PBPK) model for BaP for the rat was extended to simulate inhalation exposures to BaP in rats and humans including particle deposition and dissolution of absorbed BaP and renal elimination of 3-hydroxy benzo[a]pyrene (3-OH BaP) in huma...

Journal: :Cancer research 2004
Shih-Yin Chen Jane-Ru Vivan Lin Ramalakshmi Darbha Pinpin Lin Tsung-Yun Liu Yi-Ming Arthur Chen

Glycine N-methyltransferase (GNMT) affects genetic stability by (a) regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and (b) binding to folate. Based on the identification of GNMT as a 4 S polyaromatic hydrocarbon-binding protein, we used liver cancer cell lines that expressed GNMT either transiently or stably in cDNA transfections to analyze the role of GNMT in the benzo(a...

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