BACKGROUND An association between radioiodine therapy (RAI) for Graves' disease (GD) and the development or worsening of Graves' ophthalmopathy (GO) is widely quoted but there has been no systematic review of the evidence. AIMS We undertook a systematic review of randomized controlled trials (RCTs) to assess whether RAI for GD is associated with increased risk of ophthalmopathy compared with ...

AIM To assess levels of soluble Fas (sFas) in the sera of patients with Graves' ophthalmopathy. METHODS The subjects in this study were 43 patients with Graves' ophthalmopathy and 11 normal subjects. Serum levels of sFas were determined by sandwich enzyme linked immunosorbent assay. In addition, serum levels of thyroid stimulating antibody (TSAB) were also measured in all the patients. RESU...

PURPOSE Graves ophthalmopathy and Graves disease may be caused by the same autoimmune process. An explanation for this may be the presence of autoantibodies reacting with an autoantigen in the orbit and the thyroid gland, like the thyroid-stimulating hormone (TSH) receptor. The purpose of this study was to see if initial levels of TSH receptor antibodies, known as thyroid-stimulating immunoglob...

CASE REPORT The effect of a somatostatin analogue in a patient with Graves' ophthalmopathy is presented, including data on the dose requirements and the results of therapy. DISCUSSION There are few effective options for the management of Graves' ophthalmopathy, a cell-mediated immune co-morbidity of thyroid disease. Somatostatin analogues inhibit lymphocyte proliferation and activation, and a...

BACKGROUND Cyclic strabismus is a very rare condition of ocular motility characterized by alternating strabismus and orthotropia. We report a patient with a 48-h cycle of vertical deviation associated with dysthyroid ophthalmopathy that spontaneously resolved. CASE PRESENTATION A 40-year-old woman experienced sudden onset vertical double vision. She had already been diagnosed with hyperthyroi...

Graves ophthalmopathy (GO) usually occurs in a close temporal relationship with hyperthyroidism. It is rare in patients with normal thyroid function (euthyroid GO) and in patients with hypothyroid forms of thyroid autoimmune diseases (hypothyroid GO). We report a 52-years old man presenting in our endocrine clinic with diagnosed primary hypothyroidism 3 months back during evaluation for glaucom...

Background: In patients with Graves' ophthalmopathy, orbital decompression surgery is indicated for compressive optic neuropathy, severe corneal exposure, or for cosmetic deformity due to proptosis. Traditionally this has been performed through a transantral approach, but the associated complication rate is high. More recently, endoscopic orbital decompression has been performed successfully wi...

BACKGROUND Ophthalmopathy is a common manifestation of Graves' disease (GD) occurring in up to 50% of patients. Mild eye signs are also common in patients with Hashimoto's thyroiditis. Whilst a genetic predisposition to GD has been demonstrated this is not the case for the ophthalmopathy which often runs a separate course. OBJECTIVE We determined the prevalences of eye and eyelid signs and po...