Aspartame, an artificial sweetener, is very widely used in many foods and beverages. But there are controversies about its metabolite which is marked for its toxicity. Hence it is believed to be unsafe for human use. Previous studies have reported on methanol exposure with involvements of free radicals on excitotoxicity of neuronal apoptosis. Hence, this present study is proposed to investigate...

Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than people could possibly consume. Its safety was further confirmed through studies in several human subpopulations, includin...

BACKGROUND Aspartame (L-phenylalanine N-L-alpha-aspartyl-1-methyl ester) is an artificial sweetener with widespread applications. Previously published results have shown that among rats receiving aspartame a significant increase of lymphoreticular neoplasms, brain tumours and transitional cell tumours occurred. The aim of our short-term experiment was to investigate the biological effect of asp...

The coagulation process, including thrombin, fibrin, as well as platelets, plays an important role in hemostasis, contributing to the general well-being of humans. Fibrin formation and platelet activation are delicate processes that are under the control of many small physiological events. Any one of these many processes may be influenced or changed by external factors, including pharmaceutical...

BACKGROUND In a few animal experiments, aspartame has been linked to hematopoietic and brain cancers. Most animal studies have found no increase in the risk of these or other cancers. Data on humans are sparse for either cancer. Concern lingers regarding this widely used artificial sweetener. OBJECTIVE We investigated prospectively whether aspartame consumption is associated with the risk of ...

Brain cancer incidence rates in the United States have been increasing in both adults (1) and children (2). The possibility that aspartame, a widely ingested artificial sweetener, may be a cause of brain cancer in humans was suggested in a recent report by Olney et al. (3). From a descriptive analysis of national cancer data, they noted increased brain cancer incidence rates in the United State...

Databases The following databases and respective searches were used. • Medline/PubMed: (Sweetening Agents/adverse effects OR Saccharin OR Cyclamate* OR Aspartame OR Acetosulfame OR Acesulfame) AND (Risk Factors OR Risk OR Risk Assessment OR Neoplasm* OR Carcinoma OR Cancer OR Carcinogenic) AND (Etiology/Broad[filter] OR Prognosis/Broad[filter] OR Comparative study OR Comparative studies). • Emb...

Aspartame is an artificial sweetener of low caloric value (approximately 200 times sweeter than sucrose). Aspartame is currently permitted for use in food and beverage production in more than 90 countries. The application of aspartame in food products requires development of rapid, inexpensive and accurate method for its determination. The new assay for determination of aspartame was based on s...

Administration of the artificial sweetener aspartame (L-aspartylphenylalanylmethyl ester; 200 mg/kg) by gavage to rats caused large increments in brain and plasma levels of phenylalanine and its product tyrosine. Glucose administration (3 g/kg, by gavage, a dose sufficient to cause insulin-mediated reductions in plasma levels of the large neutral amino acids leucine, isoleucine, and valine) als...

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