Inorganic pyrophosphatase (PPiase) activity was measured in cell fractions of rat, mouse, and human erythrocytes; normal rat liver; Novikoff hepatoma; Morris 3924A hepatoma; and mouse Ehrlich and Sarcoma 37 ascites tumors. Despite high intracellular activities, when precautions were taken to maintain cell integrity, only negligible activities were found on the surface of intact erythrocytes, No...

A correlation between the capacity of tumor-bearing animals to maintain normal glucose levels and the stimula tion of gluconeogenesis from noncarbohydrate sources has been established. Gluconeogenesis was shown to counterbal ance the tendency toward hypoglycemia caused by tumors in mice with Crocker sarcoma and Guelstein 22a hepatoma, and in rats with Zajdela ascites hepatoma. Mobilization of l...

n our laboratory in 4CS mice. (3) Mouse ascites hepatoma, MH134, was converted into ascitic form by Sato et al.*\ from a C3H/HeN mouse hapatoma induced after treatment with carbon tetrachloride by Andervont et al.5) It has been maintained in C3H/He mice with distinct strain specificity in tumor take in our laboratory. (4) Mouse ascites sarcoma, SR-C3H/He Th62, was originally induced with Schmid...

Crystalline abrin isolated from Abrus precatorius L. has been shown to have a strong inhibitory effect on the protein biosynthesis of Ehrlich ascites tumor and Yoshida ascites hepatoma cells and a moderate inhibitory effect on the DNA biosynthesis of these neoplastic cells. It has no significant effects on the RNA biosynthesis and cellular respiration of these neoplastic cells at a much higher ...

This study investigates the specificity of two antigenic proteins with molecular weights of 39,000 and 49,000, respectively (p39 and p49), present in Novikoff ascites hepatoma. Chromatins and cytosol fractions were assayed from a number of tumorigenic cell lines by identifying antigenic species immunologically on nitrocellulose transfers containing proteins separated electrophoretically. Immuno...

A nineteen year old female underwent 85 to 90 per cent partial hepatectomy to treat a minimal deviation hepatoma. Observations afterwards suggested that the limit of resection compatible with survival had been reached. She recovered perfect health after many months, although liver regeneration was not complete. Severe but eventually reversible alopecia and ascites developed postoperatively, und...

To study the effects of total-body hyperthermia (TBH) on metastases from malignant tumors, Lewis lung carcinoma (LLC)-bearing C57BL/6 mice and mouse ascites hepatoma 134-bearing C3H/He mice were immersed in a heated water bath. Rectal temperature was maintained for 30 min at 40 degrees C or 42 degrees C. After treatment, the incidence of lung metastasis was analyzed in LLC-inoculated mice, and ...

BACKGROUND It is well known that various polysaccharides present anti-tumour effects by inducing cell apoptosis and immunomodulation. However, it is still unclear about the roles of polysaccharides isolated from Artemisia apiacea (HQG) to hepatoma and its underlying mechanism. The objective of the study was to examine the anti-hepatoma effects of HQG and its related mechanism. MATERIALS AND M...