BACKGROUND Gemcitabine (GEM) is widely used as an anticancer agent in several types of solid tumors. Silver nanoparticles (AgNPs) possess unique cytotoxic features and can induce apoptosis in a variety of cancer cells. In this study, we investigated whether the combination of GEM and AgNPs can exert synergistic cytotoxic effects in the human ovarian cancer cell line A2780. METHODS We synthesi...

Silver nanoparticles (AgNPs) induce the production of reactive oxygen species (ROS) and apoptosis. These effects are enhanced by smaller particles. Using live-cell imaging, we show that AgNPs induced ROS production rapidly in a size-dependent manner after exposure of cells to 70-nm and 1-nm AgNPs (AgNPs-70, AgNPs-1), but not AgNO3. Exposure of cells to 5 μg/mL each of AgNPs-70, AgNPs-1 or AgNO3...

The nanotechnology industry advances rapidly, and at the dissolution include coating them with a polymer, such as vanguard are the promising silver nanoparticles (AgNPs), which have diverse applications. These nanometer-sized particles have been shown to inhibit the ability of bacteria to produce adenosine triphosphate (ATP), a molecule necessary for chemical energy transport in cells. The anti...

A rapid synthesis of silver nanoparticles (AgNPs) using Agrimoniae herba extract as reducing agent and stabilizer (A. herba-conjugated AgNPs [AH-AgNPs]) were designed, characterized, and evaluated for antitumor therapy feasibility. In this study, critical factors in the preparation of silver nanoparticles, including extraction time, reaction temperature, the concentration of AgNO3, and A. herba...

introduction: - significant increase in usage of silver nanoparticles (agnps) in consumer products, has increased its exposures to human and animals. although there are some reports regarding the effects of agnps on complex organisms, no report was found as to its effects on neurobehavioral ontogeny. methods: to investigate the effects of maternal exposure to agnps on development of neurobehavi...

INTRODUCTION A new method for preparation of silver nanoparticles (AgNPs) based on using hydrazino-isatin derivatives in an aqueous methanol reaction medium is reported here. AgNPs were prepared using silver nitrate solubilized in a water core as the source of silver ions and 3-hydrazino-isatin derivatives (3-hydrazino-isatin [IsH] and 1-benzyl-3-hydrazino-isatin [BIsH]) solubilized in methanol...

Due to the unique antibacterial activities, silver nanoparticles (AgNPs) have been extensively used in commercial products. Anthropogenic activities have released considerable AgNPs as well as highly toxic silver ion (Ag(+)) into the aquatic environment. Our recent study revealed that ubiquitous natural organic matter (NOM) could reduce Ag(+) to AgNP under natural sunlight. However, the toxic e...

AIMS To characterize and explore the potential in extracellular biosynthesis of silver nanoparticles (AgNPs) by Penicillium chrysogenum and Aspergillus oryzae and to investigate the antifungal effect of chemically vs biologically synthesized AgNPs comparing with conventional antifungal drugs against Trichophyton rubrum. METHODS AND RESULTS Chemically synthesized AgNPs (Chem-AgNPs) coated with...

BACKGROUND Because of their antimicrobial properties, silver nanoparticles (AgNPs) have been widely used and have come into contact with the environment. In the present work, an effect of AgNPs on a standard soil organism, Folsomia candida, was studied (in comparison to silver nitrate) focusing on molecular and cellular alterations as ecotoxicological endpoints. RESULTS At the molecular level...