Linear and nonlinear toxicity criteria were derived for 2,3,7,8-tetrachlorodibenzo(p)dioxin (TCDD) using the recent National Toxicology Program rat cancer bioassay. Dose-response relationships were assessed for combined liver tumors based on lifetime average liver concentrations (LALCs) estimated with a toxicokinetic model. Rat LALC estimates at the 1% point of departure (POD) were obtained wit...

217 words. Introduction: 790 words. Discussion: 1,240 words. Abreviations : AHR: Aryl hydrocarbon receptor; AhRE: Ah receptor response element (also named XRE, for xenobiotic, and DRE, for dioxin response element); AR: Androgen receptor; ARE: Androgen receptor response element; ARNT: Aryl hydrocarbon receptor nuclear translocator; bHLH: basic region-helix-loop-helix; CDT: Charcoal-dextran treat...

Established under the Assisted Human Reproduction (AHR) Act of 2004, Assisted Human Reproduction Canada [5] (AHRC), also known as the Assisted Human Reproduction Agency of Canada, was created in 2006 to oversee research related to reproductive technologies and to protect the reproductive rights [6] and interests of Canadian citizens. AHRC serves as a regulatory body for the development and use ...

Established under the Assisted Human Reproduction (AHR) Act of 2004, Assisted Human Reproduction Canada [5] (AHRC), also known as the Assisted Human Reproduction Agency of Canada, was created in 2006 to oversee research related to reproductive technologies and to protect the reproductive rights [6] and interests of Canadian citizens. AHRC serves as a regulatory body for the development and use ...

Established under the Assisted Human Reproduction (AHR) Act of 2004, Assisted Human Reproduction Canada [5] (AHRC), also known as the Assisted Human Reproduction Agency of Canada, was created in 2006 to oversee research related to reproductive technologies and to protect the reproductive rights [6] and interests of Canadian citizens. AHRC serves as a regulatory body for the development and use ...

The first X-ray structure of an isatin (2,3-indolinedione, isaH) metal complex, bis(isatinato)memury(II) (C(16)H(8)N(2)O(4)Hg) (1), was determined. (1) was obtained from the reaction of isaH with mercury(II) acetate in methanol. Analogously, treatment of sodium saccharinate and mercury(II) acetate in methanol yielded Hg(saccharinato)(2) (*)0.5CH(3)OH (3). (1) crystallizes in the monoclinic syst...

Significant progress has been made in the direct arylation of simple arenes. A number of catalyst systems have been developed which enable the intramolecular direct arylation of aryl chlorides, bromides and iodides in high yield as well as conditions capable of achieving intermolecular direct arylation with simple arenes. This account describes recent progress by our group and others in the dev...

Established under the Assisted Human Reproduction (AHR) Act of 2004, Assisted Human Reproduction Canada [5] (AHRC), also known as the Assisted Human Reproduction Agency of Canada, was created in 2006 to oversee research related to reproductive technologies and to protect the reproductive rights [6] and interests of Canadian citizens. AHRC serves as a regulatory body for the development and use ...