The article presents the results of the application of artificial neural networks to separate the fluorescent contribution of nanodiamonds used as biomarkers, adsorbents and carriers of drugs in biomedicine, from a fluorescent background of own biological fluorophores. The principal possibility of solving this problem is shown. Use of neural network architecture let to detect fluorescence of na...

In this study, 21 structurally diverse drugs with examined central nervous system penetration were used for prediction of blood-brain barrier penetration using HPLC-UV instrument. Drugs' chromatographic capacity factors were measured by the immobilized artificial membrane presented by phosphatidylcholine column. The correlation between chromatographic capacity factor, octanol-water partition co...

background: antibiotic therapies used in treatment of many diseases have adverse effects on fertility. this review analyzes previous comparative studies that surveyed the effects of two common groups of antibiotics on male fertility. objective: to evaluate histo-pathological effects of fluoroquinolones and aminoglycosides on sperm parameters and male reproductive tissue. materials and methods: ...

one is faced with a serious problem with few drugs left to use prior to the use of a paralysant in conjunction with artificial respiration. If there is no significant tachyarrhythmia, one can try atropine solution by inhalation. Unfortunately, most patients have tachyarrhythmia precluding further use of sympathomimetic drugs or recently advocated atropine solution inhalation. During the past 8 ...

A method for the continuous perfusion of the perilymphatic space of the inner ear in the guinea pig is described. Artificial perilymph is supplied to the cochlea and drained away through a tubing system while flow rates from 10 microliters/min to 0.3 ml/min are established by gravity syphon pressure. Techniques are also presented which allow control over the temperature of the perfusate and ov...

The artificial cell is a Canadian invention (Chang, Science, 1964). This principle is being actively investigated for use in cell and organ replacements. The earliest routine clinical use of artificial cells is in the form of coated activated charcoal for hemoperfusion for use in the removal of drugs, and toxins and waste in uremia and liver failure. Encapsulated cells are being studied for the...

The use of traditional medicines including natural drugs, especially Chinese medicine (TCM), plays an important role in the prevention and treatment human diseases; however, so far, mechanism its prevention, health care diseases is unclear. Here, I propose that core to correct relative deficiency potassium ions body at same time improve utilization efficiency ions, as or restore cell functions ...

This study has selected the medium-chain saturated fatty acid pelargonic as raw material for first time, and added surface catalyst Tween 80 to aqueous solution form acid–Tween composite vesicles by a tension method. The compound vesicle was used encapsulate five heterocyclic drugs (cefazolin sodium, chlorpromazine hydrochloride, gemcitabine metronidazole, isoniazid), all of which have disadvan...

objective(s): a fast and reliable evaluation of the binding energy from a single conformation of a molecular complex is an important practical task. artificial neural networks (anns) are strong tools for predicting nonlinear functions which are used in this paper to predict binding energy. we proposed a structure that obtains binding energy using physicochemical molecular descriptions of the se...