Cardiac glycosides are potent inhibitors of cell division. They may be useful as antitumor agents if the antimitotic effect can be dissociated from their cardiotoxic effect. We studied congeners of cardiac glycosides to determine whether the saccharide or the genin portion of the molecule contributes to its antimitotic effect. The concentration of glycoside required to inhibit PHA-stimulated 3H...

The mechanism of arrhythmogenicity in heart failure remains poorly understood. We examined the relationship between electrical abnormalities and ventricular arrhythmia by using experimental heart failure models. Sixty unipolar electrograms were recorded from the entire cardiac surface in control dogs (n = 13) and pacing-induced heart failure dogs (n = 16). In failing hearts, activation time (AT...

Objectives: Our study aimed to investigate the frequency of malignant cardiac arrhythmias in hospitalized patients receiving hydroxychloroquine alone and those a combination with azithromycin, as well quantitative extent QT prolongation within Tisdale Risk Score (TRS) categories. Background: There have been over 33 million cases SARS-CoV-2 (COVID-19) resulting 600,000 deaths United States. As c...

OBJECTIVES Aging increases atrial fibrillation (AF) vulnerability. The left atrium (LA) is important for the generation of AF. However, the effect of aging on the electrophysiological properties of the LA in general, on the specific LA sites, and of possible accentuation of regional differences between the LA sites with aging is not clear. The purpose of this study was to evaluate the effects o...