Isothiourea HBTM-2.1 promotes the catalytic asymmetric α-functionalization of 3-alkenoic acids through formal [2 + 2] cycloadditions with N-tosyl aldimines and formal [4 + 2] cycloadditions with either 4-aryltrifluoromethyl enones or N-aryl-N-aroyl diazenes, providing useful synthetic building blocks in good yield and with excellent enantiocontrol (up to >99% ee). Stereodefined products are ame...

A series of benzophenone oximes appended with sydnone (3a--h) bearing different substituents on aroyl moiety were synthesized to evaluate in vivo and in vitro for their inhibitory activity against purified phospholipase A2 (PLA2) enzymes from snake venom and human inflammatory pleural and ascites fluid. In vivo and in vitro inhibition studies were carried out against PLA2 with respect to the mo...

Algorithms for classification and taxonomy are proposed based on criteria as information entropy and its production. It is classified a series of 5-amino-2-aroylquinolines (AAQs) and 4-aroyl-6,7,8-trimethoxyquinolines (TMQs) combretastatin analogues for anti-cancer activity. 5-Amino-6-methoxy-2-aroylquinoline AAQ showed anti-proliferative activity more potent as compared to combretastatin A-4 (...

The asymmetric unit of the title compound, C(19)H(16)O(3), contains three independent conformers. Each of the three conformers has essentially the same feature of non-coplanar aromatic rings whereby the aroyl group at the 1-position of the naphthalene ring is twisted in a perpendicular manner to the naphthalene ring. The dihedral angles between the benzene ring planes and the naphthalene ring s...

(+/-)-Gusanlung A, 8-oxyberberrubine and (+/-)-gusanlung D have been synthesized by radical cyclisation of the corresponding 2-aroyl-1-methylenetetra- hydroisoquinolines. The (1)H and (13)C spectra of (-)-gusanlung D were found to be different from those of synthetic (+/-)-gusanlung D. Careful analyses of the (13)C spectra of (-)-gusanlung A and natural 8-oxyberberrubine also cast doubt on the ...

Triazole and itís derivatives are noteworthy for their physiological and biological importance. They paved the attention of medicinal chemist due to their wide range of biological activities like anti-inflammatory (1ñ5), antibacterial (6ñ8), anticonvulsant (9), antifungal (10ñ14) and anticancerous (15) etc. In view of above facts and inspired by the research going on triazole and its derivative...

BACKGROUND: Rocuronium Bromide is a newer, low potency nondepolarising neuromuscular blocking agent. It is proven to be five to seven times less potent than vecuronium.The aim of the present study was to evaluate the effectiveness of 2ED95 (2 times effective dose 95) dose (0.6mg/kg) of rocuronium with regard to onset time, the intubating conditions and the duration of action and to compare it w...