Clinical data on 7840 HIV-positive patients, representing 43 745 patient-years of follow-up, has been collected. All patients with ARL since 1986 (n = 150) were assessed at presentation for prognostic factors and outcomes recorded. Comparisons are made between cases in the pre-HAART era (1988-1995), and the HAART era (1996-1999). Statistical models are used to calculate the incidence of ARL and...

In certain statistical process control applications, quality of a process or product can be characterized by a function commonly referred to as profile. Some of the potential applications of profile monitoring are cases where quality characteristic of interest is modelled using binary,multinomial or ordinal variables. In this paper, profiles with multinomial response are studied. For this purpo...

In some quality control applications, the quality of a process or a product is described by the relationship between a response variable and one or more explanatory variables, called a profile. Moreover, in most practical applications, the qualitative characteristic of a product/service is vague, uncertain and linguistic and cannot be precisely stated. The purpose of this paper is to propose a ...

The purpose of the study is to explore any nexus between Amman Stock Exchange (ASE) governance required disclosures based on auditors' determinants audit reporting lag (ARL) construct an integrated financial report (IFR). study's are revealed by terms meetings, number members, opinion, and type company. Meanwhile total assets bank performance indicated non-audit affecting disclosure IFR. hypoth...

[(S)-Alpha-phenyl-2-pyridine-ethanamine dihydrochloride] (ARL 15896AR) is a low affinity uncompetitive N-methyl-D-aspartic acid receptor antagonist that was tested in animal models of anoxia and ischemia. Pretreatment of rodents with ARL 15896AR extended survival time during exposure to hypoxia. With the rat four-vessel occlusion model of global ischemia (20 min), oral dosing commencing at refl...

The purpose of this study was to characterize the kinetics and voltage-dependence of the block of N-methyl-D-aspartate (NMDA)-induced currents in primary cultures of rat cortical neurons by the neuroprotective, low-affinity, NMDA antagonist ARL 15896AR, using whole-cell voltage-clamp techniques. ARL 15896AR caused rapid and reversible inhibition of NMDA (50 microM)-evoked currents from neurons ...

Helicases couple ATP hydrolysis to nucleic acid binding and unwinding via molecular mechanisms that remain poorly defined for most enzyme subfamilies within the superfamily 2 (SF2) helicase group. A crystal structure of the PriA SF2 DNA helicase, which governs restart of prematurely terminated replication processes in bacteria, revealed the presence of an aromatic-rich loop (ARL) on the presump...

A control chart is an important tool in statistical process monitoring that useful to monitor and improve production quality. In this article, attribute using repetitive sampling under a truncated life test proposed for the mean of product where lifetime follows Rayleigh distribution. The parameters limit coefficients are determined so in-control average run length (ARL) very close target ARL. ...

Efficient clearance of apoptotic cells by phagocytes is important for development, tissue homeostasis, and the prevention of autoimmune responses. Phagosomes containing apoptotic cells undergo acidification and mature from Rab5-positive early to Rab7-positive late stages. Phagosomes finally fuse with lysosomes to form phagolysosomes, which degrade apoptotic cells; however, the molecular mechani...

In the present studies, we have evaluated the effects of N-[4-(2-¿[(3-Chlorophenyl)methyl]amino¿ethyl)phenyl]-2-thiophenecarbo ximidamide dihydrochloride (ARL 17477) on recombinant human neuronal NOS (nNOS) and endothelial NOS (eNOS). We then carried out pharmacokinetic studies and measured cortical nitric oxide synthase (NOS) inhibition to determine that the compound crossed the blood brain ba...