In this work, we develop and evaluate polycationic nanoparticles for the delivery of small interfering RNA (siRNA). Delivery remains a major challenge for translating siRNA to the clinic, and overcoming the delivery challenge requires effective siRNA delivery vehicles that meet the demands of the specific delivery strategy. Cross-linked polycationic nanoparticle formulations were synthesized us...

Introduction Polymer brushes have promising characteristics which could lend themselves to the lubrication of hybrid contacts [1]. In this paper the interaction between surface-initiated polymer bushes grown on silicon nitride and a steel counter contact is investigated. The importance of the hybrid contact relies on silicon nitride and its unique material properties which show clear reductions...