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Anti-microRNA (miRNA) oligonucleotides (AMOs) with 2'-O-Methyl (2'OMe) residues are commonly used to study miRNA function and can achieve high potency, with low cytotoxicity. Not withstanding this, we demonstrate the sequence-dependent capacity of 2'OMe AMOs to inhibit Toll-like receptor (TLR) 7 and 8 sensing of immunostimulatory RNA, independent of their miRNA-targeting function. Through a scr...

BACKGROUNDS To investigate the inhibiting effects of multi-target anti-microRNA antisense oligonucleotide (MTg-AMOs) on proliferation and migration of human gastric cancer cells. METHODS Single anti-microRNA antisense oligonucleotides (AMOs) and MTg-AMOs for miR-221, 21, and 106a were designed and transfected into SGC7901, a gastric cancer cell line, to target the activity of these miRNAs. Th...

fails to resolve, demonstrating that, as with the selection of other neural precursors, the resolution of amos expression involves lateral inhibition. In the antennal imagi-nal disc, amos mRNA is detected in three semicircular The peripheral nervous system (PNS) is made up of an bands that correspond to the sites where olfactory sen-array of different sensory structures that detect aspects sill...

In this paper we present AmOS, the Ambient Object System that underlies the Ambience programming language. AmOS implements a computation model that supports highly dynamic behaviour adaptation to changing contexts. Apart from being purely object-based, AmOS features first-class closures, multimethods and contexts. Dynamic method scoping through a subjective dispatch mechanism is at the heart of...

S. Karataglidis,1 P. G. Hansen,1 B. A. Brown,1 K. Amos,2 and P. J. Dortmans2 1National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824-1321 2School of Physics, University of Melbourne, Parkville 3052, Victoria, Australia (Received 8 May 1997) Inelastic scattering data of 11Li from hydrogen at 68A MeV have been interpreted as the excitation of a stat...