aquaporins are integral membrane proteins from a larger family of major intrinsic proteins that formpores in the membrane of biological cells. aquaporins form tetramers in the cell membrane with eachmonomer acting as a water channel.in this research, the aqp4 tetramer was modeled from its pdbstructure file, then, we have performed the intraction of aquaporin4 in different temperatures (298k,300...

cyprinus carpio is a stenohaline species but can tolerate some ranges of changes in environmental salinities, so histomorphological methods and na+-k+ atpase and aquaporin 3 immunohistochemistry were performed on common carp kidney as an osmoregulatory organ in experimental groups and control in order to investigate their possible roles during salinity challenge. five groups of fish (n=25) with...

Devic's neuromyelitis optica is an inflammatory demyelinating disorder normally restricted to the optic nerves and spinal cord. Since the identification of a specific autoantibody directed against aquaporin 4, neuromyelitis optica-immunoglobulin G/aquaporin 4 antibody, neuromyelitis optica has been considered an entity distinct from multiple sclerosis. Recent findings indicate that the neuromye...

OBJECTIVE To compare performance of contemporary aquaporin-4-immunoglobulin (Ig) G assays in clinical service. METHODS Sera from neurologic patients (4 groups) and controls were tested initially by service ELISA (recombinant human aquaporin-4, M1 isoform) and then by cell-based fluorescence assays: fixed (CBA, M1-aquaporin-4, observer-scored) and live (fluorescence-activated cell sorting [FAC...

Aquaporins (AQPs) are membrane channel proteins which facilitate the rapid transport of water across cellular membrane and are of fundamental importance to the control of cell volume and transcellular water traffic. In the present study using bioinformatic tools an in silico modeling and analysis of aquaporin protein sequences of catfish Heteropneustes fossilis was conducted. Primary structure ...

Background: Among aflatoxins, the subtype aflatoxin G1 is one of most toxic, commonly found in cereals, legumes, dairy and non-alcoholic beers. Aflatoxins have been known as nephrotoxic compounds. In this study, changes expression aquaporin-1, histopathology renal tissue plasma biochemical factors after exposure to were investigated mice. Methods: Twenty-four adult male mice (weighing 20±2 g) d...

To the Editor: In their review article on water balance, Knepper et al. (April 2 issue)1 discuss water channels (aquaporins) in renal tubular cells. They omit mention of the critical role played by aquaporin-1 in microvascular endothelia. In the renal microvasculature, endothelial aquaporin-1 mediates the osmotic water efflux across descending vasa recta and is required for regulation of medull...

The purpose of this study was to investigate whether escape from vasopressin-induced antidiuresis is associated with altered regulation of any of the known aquaporin water channels. After 4-d pretreatment with 1-deamino-[8-D-arginine]-vasopressin (dDAVP) by osmotic mini-pump, rats were divided into two groups: control (continued dDAVP) and water-loaded (continued dDAVP plus a daily oral water l...

This paper gives a summary of a project to characterize a tobacco aquaporin. The cDNA and gene, including the 5' upstream region, for the tobacco aquaporin NtAQP1 has been isolated and the encoded protein characterized. The significance of promoter regions for an abscisic acid- and gibberellic acid-induced gene expression could be restricted to a region between -1450 and -1112 upstream of the t...

Aquaporins enable the passage of a diverse set of solutes besides water. Many novel aquaporin permeants, such as antimonite and arsenite, silicon, ammonia, and hydrogen peroxide, have been described very recently. By the same token, the number of available aquaporin sequences has rapidly increased. Yet, sequence analyses and structure models cannot reliably predict permeability properties. Even...