نتایج جستجو برای: aptt

تعداد نتایج: 1461  

ژورنال: :مجله علوم پزشکی رازی 0
عزیزا... ادیب a adib دانشگاه آزاد اسلامی واحد اردبیل بهناز فتورچی b fatourchi

در مطالعه حاضر، از میان روش های متعدد که برای تجویز داروی هپارین به عنوان پیش گیری و یا درمان بیماری های مختلف وجود دارند، 2 روش انفوزیون مداوم و تجویز منقطع از نظر تاثیر بر روی aptt در زمان های مختلف با هم مقایسه شده اند تا مزایا و معایب هر یک روشن تر شود. مطالعه به صورت کارآزمایی بالینی(تجربی مداخله گر) بر روی 423 بیمار انتخاب شده به صورت احتمالی ساده و با سنجش aptt با یک کیت مشخص و استاندارد...

2017
Jingyang Fan Billee John Emily Tesdal

Purpose: Using adjusted body weight (AdjBW) for heparin dosing in obese patients is a common but not validated clinical practice. The purpose of this study was to evaluate whether using AdjBW in obese patients would lead to quick achievement of therapeutic activated partial thromboplastin time (aPTT) and low bleeding risk with heparin therapy. Methods: A retrospective cohort study was conducted...

2011
Ying Zhao Jie Zhang Juanwen Zhang Jianping Wu

OBJECTIVE This study was designed to examine the relationship between shortened activated partial thromboplastin time (APTT) and increased fibrinogen values with diabetes mellitus. METHODS APTT, prothrombin time (PT), fibrinogen, fasting plasma glucose (FPG) and glycosylated hemoglobin A1c (HbA1c) levels were measured in 1,300 patients. Patients were divided into three groups according to the...

2018
Martin Beiderlinden Patrick Werner Astrid Bahlmann Johann Kemper Tobias Brezina Maximilian Schäfer Klaus Görlinger Holger Seidel Peter Kienbaum Tanja A Treschan

BACKGROUND Argatroban or lepirudin anticoagulation therapy in patients with heparin induced thrombocytopenia (HIT) or HIT suspect is typically monitored using the activated partial thromboplastin time (aPTT). Although aPTT correlates well with plasma levels of argatroban and lepirudin in healthy volunteers, it might not be the method of choice in critically ill patients. However, in-vivo data i...

Journal: :The journal of extra-corporeal technology 2014
Jason P Sulkowski Thomas J Preston Jennifer N Cooper Victoria L Duffy Katherine J Deans Louis G Chicoine Peter C Minneci

Our objective was to determine the best measure of heparin anticoagulation in neonatal patients on extracorporeal membrane oxygenation. Activated clotting time (ACT), activated partial thromboplastin time (aPTT), and antifactor Xa levels, along with corresponding heparin infusion rates and heparin bolus volumes, were collected from neonates receiving ECMO at our institution from 2008 to 2013. A...

Journal: :British Journal of Anaesthesia 1993

2016
Jung-Hyun Byun In-Seok Jang Jong Woo Kim Eun-Ha Koh

BACKGROUND Unfractionated heparin (UFH) has unstable pharmacokinetics and requires close monitoring. The activated partial thromboplastin time (aPTT) test has been used to monitor UFH therapy for decades in Korea, but its results can be affected by numerous variables. We established an aPTT heparin therapeutic range (HTR) corresponding to therapeutic anti-Xa levels for continuous intravenous UF...

Journal: :Veterinaria italiana 2017
Maria Marília Leite Carlos Marília Martins Melo Benito Soto-Blanco

Haemostasis is a physiological process that prevents excessive blood loss. In laboratory, the prothrombin time (PT) and the activated partial thromboplastin time (aPTT) are used to examine clotting systems. However, the influence of sex on PT and aPTT values is unknown. The present work aimed to determine the values for PT and aPTT in adult sheep and to evaluate their dependence on the sex of t...

2012
Mark T Reding David L Cooper

BACKGROUND Bleeding symptoms commonly seen by multiple physician specialties may belie undiagnosed congenital or acquired bleeding disorders. Acquired hemophilia is a potentially life-threatening cause of unexplained acute bleeding manifested by an abnormal activated partial thromboplastin time (aPTT) that does not correct with 1:1 mixing with normal plasma. METHODS Practicing physicians (hem...

Journal: :iranian journal of pharmaceutical sciences 0
mojtaba mojtahedzadeh department of clinical pharmacy, faculty of pharmacy hossein khalili department of clinical pharmacy, faculty of pharmacy ali mohagheghi department of cardiology, faculty of medicine, tehran university of medical sciences, tehran, iran simin dashti-khavidakia department of clinical pharmacy, faculty of pharmacy

nitroglycerin has been reported to reduce activated partial thromboplastin time (aptt) values in patients treated with concurrent heparin and nitroglycerin. however, studies have yielded conflicting results. to determine whether intravenous nitroglycerin alters the anticoagulant effect of heparin, we prospectively evaluated twenty patients admitted for coronary angioplasty by measuring their ap...

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