Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4). Materials and Methods: The acute liver injury model was produced by CCl4 at 10 ml/kg body weight in 24-...

background: apoptosis is a process that plays an important role during early stage of implantation. the aim of this study was to investigate the incidence of apoptosis in mice endometrium after ovarian stimulation at implantation period. methods: nmri female mice were divided into two groups: 1) control group, which were rendered pseudopregnant by vaginal stimulation and 2) experimental group, ...

Abstract Objective Definitive chemoradiotherapy (dCRT) is one of the standard treatments for esophageal squamous cell carcinoma (ESCC), but local recurrence main cause treatment failure. The changes in apoptosis and autophagy recurrent tumors patients with ESCC following dCRT have been poorly estimated. Thus, this study aimed to investigate expressions key regulators matched paired samples prim...

background: toxic effects of anti-cancer and other drugs on the normal tissues could be reduced by the herbal plants and their fractions. this study investigated the protective effect of thymoquinone (tq) as a fraction of nigella sativa on methotrexate (mtx)- induced germ cell apoptosis in male mice. materials and methods: in this experimental study, thirty male balb/c mice were divided randoml...

Odontogenic tumors contain a heterogeneous collection of lesions that are categorized from hamartomas to benign and malignant neoplasms of inconstant aggressiveness. Odontogenic tumors are usually extraordinary with assessed frequency of short of 0.5 cases/100,000 population for every year. The lesions such as odontogenic tumors are inferred from the components of the tooth-structuring contrapt...

Abalone ( Haliotis discus hannai Ino) is one of the most vital economic shellfish cultured in China. However, bacterial and viral infection often leads to its high mortality serious losses. In this study, transcriptome sequencing was performed on gill abalone challenged by Vibrio parahaemolyticus for 0 h (control group, A0h), 8 (A8h), 48 (A48h), respectively. Each library has an average 53,361,...

Introduction Identification of Alzheimer's Disease (AD)-related transcriptomic signatures from blood is important for early diagnosis the disease. Deep learning techniques are potent classifiers AD diagnosis, but most have been unable to identify biomarkers because their lack interpretability. Methods To address these challenges, we propose a pathway information-based neural network (PINNet) pr...