We investigated the effect of antibodies to heat-shock proteins 60 and 70 on development, reactive oxygen species production, and incidence of apoptosis in preimplantation mouse embryos. Supplementation of culture media with antibodies to heat-shock proteins 60 and 70 resulted in significantly lower blastocyst development, hatching rate, reduced total cell number, and trophectoderm cell number,...

background: multiple sclerosis (ms) is an autoimmune disease of central nerves system, in which neurological disabilities occur in young adults. despite increasing number of studies on ms, some aspects of this disorder are still unclear. in the previous studies, it has been proven that there is direct relation between ms incidence and vitamin d deficiency. thereby, strong evidence in ms pathoge...

Tobacco smoking is a major risk factor for human cancers including urinary bladder carcinoma. In previous study, nicotine enhanced rat carcinogenesis in two-stage model. Nicotine also induced cytotoxicity the urothelium short-term study. present male rats were treated with (40 ppm) drinking water co-administered NADPH oxidase inhibitor, apocynin (0, 250 or 750 mg/kg) diet 4 weeks. The treatment...

The incidence of oral cancer is lower than that of other common cancers. Understanding the factors that contribute to the decreased incidence of oral cancer may be useful for decreasing the incidence of cancer overall. We focused on the effects of hydrogen sulfide, which is produced by oral bacteria. We report that hydrogen sulfide induced apoptosis in gingival cancer cells that overexpressed p...

The purpose of this study was to evaluate the effect preventive acupuncture combined with CMNS6-1 electroacupuncture on 7,12-dimethylbenzanthracene induced mammary tumors in Sprague-Dawley rats and explore from perspective apoptosis. 48 w old female were randomly divided into control (10), model tamoxifen (10) groups. group, group administered once intragastrically 100 mg/kg body weight induce ...

Inactivation of the maternally imprinted, paternally expressed gene 3 (Peg3) induces deficits in olfactory function, sexual and maternal behaviors, oxytocin neuron number, metabolic homeostasis and growth. Peg3 is expressed in a number of developing hypothalamic and basal forebrain structures and is a component of the P53 apoptosis pathway. Peg3 inactivation in neuronal cell culture lines inhib...

Studies in our laboratories showed that overexpression of manganese superoxide dismutase (MnSOD) reduced tumor incidence in a multistage skin carcinogenesis mouse model. However, reduction of MnSOD by heterozygous knockout of the MnSOD gene (MnSOD KO) did not lead to an increase in tumor incidence, because a reduction of MnSOD enhanced both cell proliferation and apoptosis. The present study ex...

Background Today, cryopreservation of ovarian tissue has been the effective procedure to restore fertility in can cer patients. It is well known that oxidative stress (OS) is a widespread phenomenon that occurs in ovary cryopreservation. Numerous studies show that follicular atresia in mammalian species due to the accumulation of toxic metabolites often results from oxidative stress. Therefore,...

Cervical cancer ranks third in incidence worldwide and is the most frequent gynecological developing countries. This study aimed to investigate effect of crocin on resistance HELA/Ara-C cells chemo-agent Ara-C. which was defined as Ara-C-resistant HELA cell line, were treated with crocin. After that, proliferation, apoptosis, cycle assay examined by MTT assay, AO/EB staining, flow cytometry, re...